INT331341

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.80
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Mir483 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 10 74.32 Quite High
Glutamate 10 70.36 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 32 82.04 Quite High
Infection 36 80.36 Quite High
American Trypanosomiasis 10 69.68 Quite High
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Parasitic Infection 4 5.00 Very Low Very Low Very Low
Heart Disease 2 5.00 Very Low Very Low Very Low
Bites And Stings 2 5.00 Very Low Very Low Very Low
Parasitemia 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate that WRR-483 is an effective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777.
Negative_regulation (inhibitor) of WRR-483
1) Confidence 0.02 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2939063 Disease Relevance 0.80 Pain Relevance 0.04
Also, we have previously demonstrated that WRR-483 is a potent inhibitor of the cathepsin L-like cysteine protease, EhCP1, of E. histolytica, and is much more effective against EhCP1 than K11777. [39] Thus, it is possible that WRR-483 is targeting an as yet unidentified cathepsin L-like cysteine protease in T. cruzi as well.
Negative_regulation (inhibitor) of WRR-483
2) Confidence 0.02 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0 Pain Relevance 0.04

General Comments

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