INT331342

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.78 Pain Relevance 0.10

Mir483 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate 10 74.88 Potency 10 74.32 Inflammation 4 5.00 alcohol 4 5.00 Bioavailability 4 5.00 addiction 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Disease 32 82.04 Infection 36 80.36 American Trypanosomiasis 10 67.44 INFLAMMATION 4 5.00 Parasitic Infection 4 5.00 Heart Disease 2 5.00 Bites And Stings 2 5.00 Parasitemia 2 5.00 Body Weight 2 5.00 Death 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We demonstrate that WRR-483 is an effective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777.

Positive_regulation (effective) of WRR-483

1) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2939063 Disease Relevance 0.78 Pain Relevance 0.04

Other potential targets include the cathepsin B-like protease[40] and cruzipain-2, an isoform of cruzain which was reported to be active against substrates containing an arginine group in the P2 position.[41] Protease profiling studies indicate that WRR-483 is only active against a few members of the cathepsin family.

Positive_regulation (active) of WRR-483

2) Confidence 0.02 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0 Pain Relevance 0.06

General Comments

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