INT331343

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.39 Pain Relevance 0.03

Mir483 (Mus musculus)

Pain Link Frequency Relevance Heat Potency 5 64.84 Inflammation 2 28.72 Glutamate 5 5.00 alcohol 2 5.00 Bioavailability 2 5.00 addiction 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Infection 18 99.70 Disease 16 74.24 INFLAMMATION 2 28.72 American Trypanosomiasis 5 5.00 Parasitic Infection 2 5.00 Heart Disease 1 5.00 Bites And Stings 1 5.00 Parasitemia 1 5.00 Body Weight 1 5.00 Death 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Determination of dose response of the activity of WRR-483 against T. cruzi infection in BESM cells demonstrated that WRR-483 had an EC50 of 0.2 µM, which was more effective than K11777 and comparable to posaconazole (EC50?

Positive_regulation (demonstrated) of Gene_expression (had) of WRR-483 associated with infection

1) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0.39 Pain Relevance 0.03

General Comments

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