INT331403

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Context Info
Confidence 0.75
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.19
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Mboat4) transferase activity, transferring acyl groups (Mboat4)
Anatomy Link Frequency
stomach epithelium 1
tongue 1
taste buds 1
Mboat4 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 77 82.76 Quite High
Serotonin 28 5.00 Very Low Very Low Very Low
Action potential 21 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
midbrain 7 5.00 Very Low Very Low Very Low
member 8 7 5.00 Very Low Very Low Very Low
TRP channel 7 5.00 Very Low Very Low Very Low
adenocard 7 5.00 Very Low Very Low Very Low
Ventral tegmentum 7 5.00 Very Low Very Low Very Low
Neuropeptide 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 7 75.24 Quite High
Dysgeusia 7 48.16 Quite Low
Salivary Gland Disease 14 26.12 Quite Low
Targeted Disruption 21 5.00 Very Low Very Low Very Low
Polycystic Kidney Disease 14 5.00 Very Low Very Low Very Low
Aids-related Complex 7 5.00 Very Low Very Low Very Low
Body Weight 7 5.00 Very Low Very Low Very Low
Aging 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that GOAT and ghrelin are also co-localized in many cells, however we did also identify ghrelin immunopositive cells in which no GOAT was expressed (Figure 5D).
Neg (no) Gene_expression (expressed) of GOAT
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.05 Pain Relevance 0.03
GOAT and GHSR are expressed in the TCs of WT mice
Gene_expression (expressed) of GOAT
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.08 Pain Relevance 0.04
Prepro-ghrelin, prohormone convertase 1/3 (PC 1/3), ghrelin, its cognate receptor (GHSR), and ghrelin-O-acyltransferase (GOAT , the enzyme that activates ghrelin) are expressed in Type I, II, III and IV taste cells of mouse taste buds.
Gene_expression (expressed) of GOAT in taste buds
3) Confidence 0.75 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0
Therefore a subset of ghrelin immunopositive cells was found to contain no discernable GOAT expression.
Neg (no) Gene_expression (expression) of GOAT
4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0.03
This indicates that the ghrelin precursor prepro-ghrelin, ghrelin, the ghrelin-cleaving enzyme PC1/3, and GOAT are all expressed in TCs.
Gene_expression (expressed) of GOAT
5) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.06 Pain Relevance 0
To corroborate our immuno-fluorescence data, we used quantitative real-time PCR to demonstrate that ghrelin, GOAT and GHSR mRNA, were expressed in both tongue and stomach epithelium, as expected (Figure 1C, See Table S1 for primer sequences).
Gene_expression (expressed) of GOAT in stomach epithelium
6) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0
To corroborate our immuno-fluorescence data, we used quantitative real-time PCR to demonstrate that ghrelin, GOAT and GHSR mRNA, were expressed in both tongue and stomach epithelium, as expected (Figure 1C, See Table S1 for primer sequences).
Gene_expression (expressed) of GOAT in tongue
7) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0

General Comments

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