INT33142

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Context Info
Confidence 0.01
First Reported 1982
Last Reported 1993
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.50
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleolus (Pck1) plasma membrane (Npr1)
intracellular (Npr1) nucleus (Pck1) lipid metabolic process (Pck1)
Anatomy Link Frequency
cerebral cortex 1
Pck1 (Rattus norvegicus)
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 2 98.66 Very High Very High Very High
cerebral cortex 2 97.72 Very High Very High Very High
Dopamine 1 93.28 High High
Clonidine 4 92.36 High High
Morphine 3 86.16 High High
agonist 2 76.80 Quite High
Potency 1 76.16 Quite High
opioid receptor 2 75.00 Quite High
Neurotransmitter 1 75.00 Quite High
Enkephalin 1 63.80 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 99.66 Very High Very High Very High
Vibrio Infection 4 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that alpha 2-receptor stimulation causes inhibitory influences on adenylate cyclase activity mediated by the inhibitory GTP binding regulatory protein in synaptic membranes of rat cerebral cortex.
GTP Positive_regulation (mediated) of cyclase in cerebral cortex associated with cerebral cortex
1) Confidence 0.01 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2995588 Disease Relevance 0.16 Pain Relevance 0.22
The K0.5 value for the GTP stimulation of the cyclase was 47 nM, and the value for the GTP inhibition was 4.5 microM.
GTP Positive_regulation (stimulation) of cyclase
2) Confidence 0.01 Published 1982 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7176222 Disease Relevance 0 Pain Relevance 0.26
Pretreatment of the membranes with islet-activating protein and NAD resulted in a significant increase in basal activity as well as in GTP- or forskolin/GTP-induced elevation of adenylate cyclase activity.
GTP Positive_regulation (elevation) of cyclase
3) Confidence 0.01 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2995588 Disease Relevance 0.15 Pain Relevance 0.07
Thus, the synergistic interaction appears to result from opioid- and muscarinic-induced activation of a pertussis toxin-sensitive GTP-binding protein which may potentiate the adenylyl cyclase stimulation by the stimulatory GTP-binding protein activated by either VIP or CRH receptors.
GTP Spec (may) Positive_regulation (potentiate) of cyclase associated with bordatella infection and opioid
4) Confidence 0.01 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8245971 Disease Relevance 0.19 Pain Relevance 0.47

General Comments

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