INT33149

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Context Info
Confidence 0.29
First Reported 1985
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.67
Pain Relevance 5.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neutrophils 6
IGKV1D-39 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 38 100.00 Very High Very High Very High
narcan 20 99.98 Very High Very High Very High
Morphine 4 99.86 Very High Very High Very High
Opioid 2 99.84 Very High Very High Very High
agonist 8 99.66 Very High Very High Very High
Potency 2 99.62 Very High Very High Very High
antagonist 4 99.58 Very High Very High Very High
opiate 6 99.50 Very High Very High Very High
opioid receptor 6 80.04 Quite High
Disease Link Frequency Relevance Heat
Sepsis 2 99.26 Very High Very High Very High
Disease 2 89.48 High High
Adult Respiratory Distress Syndrome 4 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another opiate antagonist, nalorphine, as well as the opiate agonist, morphine, also inhibited O2- release in the same concentration range.
Negative_regulation (inhibited) of Localization (release) of O2 associated with antagonist, agonist, opiate and morphine
1) Confidence 0.29 Published 1985 Journal Life Sci. Section Abstract Doc Link 2995744 Disease Relevance 0.08 Pain Relevance 0.92
Neutrophils were pre-incubated with the range of concentrations of (-) naloxone that is administered in models of experimental sepsis (10(-6) - 10(-4.5) M). (-) Naloxone inhibited O2- release in a dose dependent manner. 02- produced by a cell-free xanthine-xanthine oxidase system was not inhibited by (-) naloxone, indicating that (-) naloxone was not scavanging O2-.
Negative_regulation (inhibited) of Localization (release) of O2 in Neutrophils associated with narcan and sepsis
2) Confidence 0.26 Published 1985 Journal Life Sci. Section Abstract Doc Link 2995744 Disease Relevance 0.10 Pain Relevance 0.76
Opioid antagonist naloxone (10(-5) M) abrogated the effect of MENK on O2- release.
Negative_regulation (abrogated) of Localization (release) of O2 associated with antagonist, narcan, enkephalin and opioid
3) Confidence 0.21 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837964 Disease Relevance 0 Pain Relevance 1.27
While MENK predominantly stimulated, TGG suppressed O2- release.
Negative_regulation (suppressed) of Localization (release) of O2 associated with enkephalin
4) Confidence 0.18 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837964 Disease Relevance 0 Pain Relevance 1.27
Using human neutrophils as a source of O-2, and an assay for O-2 based upon the reduction of cytochrome C, we found that prostaglandin D2 (PGD2), leucine enkephalin (LE), and methionine enkephalin (ME) inhibited O-2 release.
Negative_regulation (inhibited) of Localization (release) of O-2 in neutrophils associated with enkephalin
5) Confidence 0.09 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3023754 Disease Relevance 0.27 Pain Relevance 0.68
There was no correlation between the potency of the inhibitory effect on O-2 release and the effect of these agents on the binding of [3H] FMLP to human neutrophils.
Negative_regulation (effect) of Localization (release) of O-2 in neutrophils associated with potency
6) Confidence 0.08 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3023754 Disease Relevance 0.22 Pain Relevance 0.65

General Comments

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