INT33149

Context Info Confidence 0.29 First Reported 1985 Last Reported 1995 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 0.67 Pain Relevance 5.56

Anatomy Link Frequency neutrophils 6 IGKV1D-39 (Homo sapiens)

Pain Link Frequency Relevance Heat Enkephalin 38 100.00 narcan 20 99.98 Morphine 4 99.86 Opioid 2 99.84 agonist 8 99.66 Potency 2 99.62 antagonist 4 99.58 opiate 6 99.50 opioid receptor 6 80.04

Disease Link Frequency Relevance Heat Sepsis 2 99.26 Disease 2 89.48 Adult Respiratory Distress Syndrome 4 88.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Another opiate antagonist, nalorphine, as well as the opiate agonist, morphine, also inhibited O2- release in the same concentration range.

Negative_regulation (inhibited) of Localization (release) of O2 associated with antagonist, agonist, opiate and morphine

1) Confidence 0.29 Published 1985 Journal Life Sci. Section Abstract Doc Link 2995744 Disease Relevance 0.08 Pain Relevance 0.92

Neutrophils were pre-incubated with the range of concentrations of (-) naloxone that is administered in models of experimental sepsis (10(-6) - 10(-4.5) M). (-) Naloxone inhibited O2- release in a dose dependent manner. 02- produced by a cell-free xanthine-xanthine oxidase system was not inhibited by (-) naloxone, indicating that (-) naloxone was not scavanging O2-.

Negative_regulation (inhibited) of Localization (release) of O2 in Neutrophils associated with narcan and sepsis

2) Confidence 0.26 Published 1985 Journal Life Sci. Section Abstract Doc Link 2995744 Disease Relevance 0.10 Pain Relevance 0.76

Opioid antagonist naloxone (10(-5) M) abrogated the effect of MENK on O2- release.

Negative_regulation (abrogated) of Localization (release) of O2 associated with antagonist, narcan, enkephalin and opioid

3) Confidence 0.21 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837964 Disease Relevance 0 Pain Relevance 1.27

While MENK predominantly stimulated, TGG suppressed O2- release.

Negative_regulation (suppressed) of Localization (release) of O2 associated with enkephalin

4) Confidence 0.18 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837964 Disease Relevance 0 Pain Relevance 1.27

Using human neutrophils as a source of O-2, and an assay for O-2 based upon the reduction of cytochrome C, we found that prostaglandin D2 (PGD2), leucine enkephalin (LE), and methionine enkephalin (ME) inhibited O-2 release.

Negative_regulation (inhibited) of Localization (release) of O-2 in neutrophils associated with enkephalin

5) Confidence 0.09 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3023754 Disease Relevance 0.27 Pain Relevance 0.68

There was no correlation between the potency of the inhibitory effect on O-2 release and the effect of these agents on the binding of [3H] FMLP to human neutrophils.

Negative_regulation (effect) of Localization (release) of O-2 in neutrophils associated with potency

6) Confidence 0.08 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3023754 Disease Relevance 0.22 Pain Relevance 0.65

General Comments

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