INT3315

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1978
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 14.73
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
plasma 4
muscle 2
skeletal muscle 2
muscle cells 2
neuronal 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 49 100.00 Very High Very High Very High
cytokine 79 99.72 Very High Very High Very High
Pain 20 99.72 Very High Very High Very High
Clonidine 8 99.72 Very High Very High Very High
tolerance 19 99.10 Very High Very High Very High
Inflammation 128 94.48 High High
Fibrositis 2 93.92 High High
headache 6 91.76 High High
Central nervous system 7 84.16 Quite High
Bioavailability 7 74.92 Quite High
Disease Link Frequency Relevance Heat
Obesity 415 100.00 Very High Very High Very High
Depression 54 100.00 Very High Very High Very High
Hyperinsulinism 19 100.00 Very High Very High Very High
Diabetes Mellitus 465 99.98 Very High Very High Very High
Schizophrenia 50 99.76 Very High Very High Very High
Stress 52 99.38 Very High Very High Very High
Impaired Glucose Tolerance 21 99.10 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

6 98.96 Very High Very High Very High
Disease 168 98.80 Very High Very High Very High
Overweight 60 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Her insulin requirement was also reduced.
Negative_regulation (reduced) of Positive_regulation (requirement) of insulin
1) Confidence 0.57 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2792735 Disease Relevance 1.67 Pain Relevance 0.14
In this way, hepatic glucose production and subsequent increased insulin requirement are reduced.
Negative_regulation (reduced) of Positive_regulation (requirement) of insulin associated with hyperinsulinism
2) Confidence 0.50 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883206 Disease Relevance 0.77 Pain Relevance 0.03
However, there is a strong need for studies on the basal insulin for prolonged pulmonary delivery as several companies are developing fast acting insulin for pulmonary delivery5152.
Negative_regulation (developing) of Positive_regulation (acting) of insulin
3) Confidence 0.43 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792528 Disease Relevance 0.14 Pain Relevance 0
Equivalence dosing of inhaled insulin
Negative_regulation (dosing) of Positive_regulation (inhaled) of insulin
4) Confidence 0.43 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835554 Disease Relevance 0.22 Pain Relevance 0.07
We report the first type I diabetic patient with an established kidney transplant on basal cyclosporin immunosuppression who was able to eliminate the insulin requirement after human islet transplantation into the portal vein.
Negative_regulation (eliminate) of Positive_regulation (requirement) of insulin in portal vein associated with diabetes mellitus
5) Confidence 0.42 Published 1990 Journal Diabetes Section Abstract Doc Link 2108071 Disease Relevance 0.35 Pain Relevance 0.07
Specifically, the insulin dose-related increases in the phosphorylation of PKB and p70S6k and dose-dependent decreases in the phosphorylation of eEF2 are not reflected in any way by dose-related changes in MPS or leg turnover.
Negative_regulation (decreases) of Positive_regulation (increases) of insulin in leg
6) Confidence 0.39 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle.
Negative_regulation (impairs) of Positive_regulation (stimulation) of insulin in skeletal muscle associated with cytokine
7) Confidence 0.37 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Title Doc Link 10893341 Disease Relevance 0.57 Pain Relevance 0.19
In summary, the physiological stress associated with muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase, presumably leading to decreased insulin-mediated glucose uptake.
Negative_regulation (impairs) of Positive_regulation (stimulation) of insulin in muscle associated with stress
8) Confidence 0.37 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.36 Pain Relevance 0.03
Acute insulin response (3 min after IVGTT) and insulin release (area between 0 and 10 min) were significantly reduced after clonidine treatment.
Negative_regulation (reduced) of Positive_regulation (response) of insulin associated with hyperinsulinism and clonidine
9) Confidence 0.37 Published 1978 Journal Acta Diabetol Lat Section Abstract Doc Link 707001 Disease Relevance 0.42 Pain Relevance 0.73
The improvement in glucose values and the degree of reduction in insulin requirement were the greatest in groups 2 and 3 and the patients in those groups had the highest free IGF-I levels.
Negative_regulation (reduction) of Positive_regulation (requirement) of insulin
10) Confidence 0.37 Published 2005 Journal Growth Horm. IGF Res. Section Abstract Doc Link 16005252 Disease Relevance 0.39 Pain Relevance 0.09
The combination of insulin-like growth factor I and insulin-like growth factor-binding protein-3 reduces insulin requirements in insulin-dependent type 1 diabetes: evidence for in vivo biological activity.
Negative_regulation (reduces) of Positive_regulation (requirements) of insulin associated with diabetes mellitus
11) Confidence 0.33 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 10770191 Disease Relevance 0.19 Pain Relevance 0
These findings indicate that IGF-I/IGFBP-3 is biologically active on carbohydrate metabolism, as measured by a decrease in insulin requirements in patients with type 1 diabetes.
Negative_regulation (decrease) of Positive_regulation (requirements) of insulin associated with diabetes mellitus
12) Confidence 0.33 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10770191 Disease Relevance 0.70 Pain Relevance 0.18
-cells, (Figure 4) declined progressively in the NPI cell monolayers cocultured with ESC, as compared to untreated NPI cell monolayers however, difference was statistically significant only for the 21 day-treated NPI (P < .050); (b) the percentage of NPI double positive for PDX-1/insulin, a mature  ?
Negative_regulation (positive) of Positive_regulation (percentage) of insulin
13) Confidence 0.32 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
In patients with type 1 and 2 diabetes mellitus, insulin sensitivity is significantly improved, insulin requirements are reduced, and glycemic control of dyslipidemia is generally improved in short-term studies. rhIGF-1 is a particularly attractive possibility in patients with type 2 diabetes mellitus, where insulin resistance is the fundamental problem.
Negative_regulation (reduced) of Positive_regulation (requirements) of insulin associated with diabetes mellitus and insulin resistance
14) Confidence 0.32 Published 2002 Journal Treat Endocrinol Section Abstract Doc Link 15832492 Disease Relevance 1.21 Pain Relevance 0.14
Thus, four (57.1%) of the patients became insulin independent, and insulin requirements decreased in all patients after the first transplantation (Table 3).
Negative_regulation (decreased) of Positive_regulation (requirements) of insulin
15) Confidence 0.31 Published 2008 Journal Diabetes Section Body Doc Link PMC2551676 Disease Relevance 0.07 Pain Relevance 0
Acute insulin response (AIR) is the increment in the plasma insulin concentration above baseline in the first 8 minutes after glucose administration and is used as a sensitive measure of ?
Negative_regulation (used) of Positive_regulation (response) of insulin in plasma associated with hyperinsulinism
16) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2872762 Disease Relevance 0.40 Pain Relevance 0.04
Rh/IGF-I/rhIGFBP-3 administration to patients with type 2 diabetes mellitus reduces insulin requirements while also lowering fasting glucose.
Negative_regulation (reduces) of Positive_regulation (requirements) of insulin associated with diabetes mellitus
17) Confidence 0.27 Published 2005 Journal Growth Horm. IGF Res. Section Title Doc Link 16005252 Disease Relevance 0.45 Pain Relevance 0
By using mature cultures of hippocampal neurons it was found that A-beta soluble oligomers (also known as ADDLs) caused loss of the activation of insulin receptors (IR) on the neuronal surface, and this event was linked to disruption of insulin signaling [13].
Negative_regulation (loss) of Positive_regulation (activation) of insulin in neuronal
18) Confidence 0.25 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 0.86 Pain Relevance 0
kg reduction in subcutaneous fat (8%) and a 36% increase in insulin sensitivity (Table 1).
Negative_regulation (reduction) of Positive_regulation (increase) of insulin in fat
19) Confidence 0.24 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.10 Pain Relevance 0
Sustained decreases in BMI and insulin requirements were observed in patients remaining on the VLCD for at least 6 weeks when compared with those of the control group [154].


Negative_regulation (decreases) of Positive_regulation (requirements) of insulin associated with obesity
20) Confidence 0.18 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 0.69 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox