INT33150

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Context Info
Confidence 0.34
First Reported 1985
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.68
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
portal vein 1
body 1
IGKV1D-39 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 4 99.86 Very High Very High Very High
agonist 3 99.66 Very High Very High Very High
narcan 18 99.58 Very High Very High Very High
opiate 6 99.50 Very High Very High Very High
antagonist 7 98.80 Very High Very High Very High
Potency 1 89.48 High High
Arthritis 2 89.36 High High
Analgesic 10 85.36 High High
Enkephalin 8 84.28 Quite High
Inflammation 64 83.24 Quite High
Disease Link Frequency Relevance Heat
Stress 9 97.52 Very High Very High Very High
Disease 20 94.96 High High
Hypothermia 6 92.64 High High
Adhesions 86 92.48 High High
Injury 3 92.48 High High
Arthritis 2 89.36 High High
Diabetes Mellitus 3 88.08 High High
Atherosclerosis 7 87.68 High High
Sepsis 2 87.08 High High
Cancer 11 85.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the temporary occlusion of the portal vein, the woman showed a marked decrease in ShvO2, significantly lower than 20%, and continued for about one hour, but on the other hand the man did not.
Negative_regulation (decrease) of ShvO2 in portal vein
1) Confidence 0.34 Published 2002 Journal Masui Section Abstract Doc Link 12134651 Disease Relevance 0.33 Pain Relevance 0.07
But as the body temperature was raised, they showed the same tendency of decreased ShvO2.
Negative_regulation (decreased) of ShvO2 in body
2) Confidence 0.34 Published 2002 Journal Masui Section Abstract Doc Link 12134651 Disease Relevance 0.31 Pain Relevance 0.07
Another opiate antagonist, nalorphine, as well as the opiate agonist, morphine, also inhibited O2- release in the same concentration range.
Negative_regulation (inhibited) of O2 associated with antagonist, agonist, opiate and morphine
3) Confidence 0.29 Published 1985 Journal Life Sci. Section Abstract Doc Link 2995744 Disease Relevance 0.08 Pain Relevance 0.92
There was no difference between the effect of (-) and (+) naloxone suggesting that the inhibition of O2- was not specific for an opiate receptor.
Negative_regulation (inhibition) of O2 associated with narcan and opiate
4) Confidence 0.26 Published 1985 Journal Life Sci. Section Abstract Doc Link 2995744 Disease Relevance 0.09 Pain Relevance 0.90
Comparison of different but structurally related prostaglandins (PGD2, PGE2, and PGF2 alpha) revealed that PGD2 was more potent than PGE2 in inhibiting O-2 and that PGF2 alpha had no effect.
Negative_regulation (inhibiting) of O-2
5) Confidence 0.11 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3023754 Disease Relevance 0.19 Pain Relevance 0.59
Therefore the ability of these [1,8] naphthyridine derivatives to inhibit O2-. production demonstrates their role in modulating oxidative stress and suggests their potential use in various degenerative diseases.


Negative_regulation (inhibit) of O2 associated with stress and disease
6) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.64 Pain Relevance 0.04
The compounds' effects on the production of reactive oxygen species (ROS) by human polymorphonuclear cells (PMNs) were studied in an in vitro cell model, evaluating inhibition of superoxide anion (O2-.) production induced by N-formylmethionyl-leucyl-phenylalanine (FMLP).
Negative_regulation (inhibition) of O2
7) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1435878 Disease Relevance 0.62 Pain Relevance 0.46
reduction of molecular oxygen (O2) to the superoxide anion
Negative_regulation (reduction) of O2
8) Confidence 0.02 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.41 Pain Relevance 0

General Comments

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