INT331560

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.21
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Mr1)
Anatomy Link Frequency
MR1 1
T cell 1
Mr1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 12 98.88 Very High Very High Very High
tolerance 30 50.00 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphopenia 36 98.08 Very High Very High Very High
Disease 16 50.88 Quite High
Diabetes Mellitus 28 46.88 Quite Low
Targeted Disruption 12 30.52 Quite Low
Autoimmune Disease 32 5.00 Very Low Very Low Very Low
Hyperglycemia 8 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Immunotherapy Of Cancer 4 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether the blocking effect of MR1 on HNT CD4+ T cell proliferation was driven by lymphopenia and/or the HA antigen, we performed adoptive transfer experiments in lymphopenic MR1 treated BALB/c mice.
Spec (whether) Negative_regulation (effect) of MR1 in T cell associated with lymphopenia
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.21 Pain Relevance 0
Purified anti-CD40L (clone MR1, Hamster IgG (BioXcell): 0.5 mg/mouse suspended in PBS) was administered by i.p. injection every other day starting on day 1 after transfer until mice were hyperglycemic.
Negative_regulation (administered) of MR1 in MR1
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0 Pain Relevance 0.05

General Comments

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