INT331564

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Apcs, Cd40) extracellular region (Apcs, Cd40) plasma membrane (Cd40)
enzyme binding (Cd40) protein complex assembly (Apcs) protein complex (Apcs)
Anatomy Link Frequency
T cells 2
Apcs (Mus musculus)
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 68.68 Quite High
tolerance 30 50.00 Quite Low
cytokine 12 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 32 99.28 Very High Very High Very High
Lymphopenia 36 82.64 Quite High
INFLAMMATION 6 68.68 Quite High
Infection 2 59.68 Quite High
Diabetes Mellitus 28 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Hyperglycemia 8 5.00 Very Low Very Low Very Low
Immunotherapy Of Cancer 4 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous reports have shown that CD4 help could be fully or partially independent of the CD40L/CD40 pathway [31], [55], [56], but our finding was somewhat surprising in light of a recent study showing that CD8+ T cells proliferating under lymphopenic conditions required CD4 help to induce autoimmunity and that this help was mediated by CD40 engagement on APCs [30].
APCs Binding (engagement) of CD40 in T cells associated with autoimmune disease
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.37 Pain Relevance 0.06
Previous reports have shown that CD4 help could be fully or partially independent of the CD40L/CD40 pathway [31], [55], [56], but our finding was somewhat surprising in light of a recent study showing that CD8+ T cells proliferating under lymphopenic conditions required CD4 help to induce autoimmunity and that this help was mediated by CD40 engagement on APCs [30].
APCs Binding (engagement) of CD40 in T cells associated with autoimmune disease
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.37 Pain Relevance 0.06

General Comments

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