INT331696

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf4) extracellular region (Fgf4)
Anatomy Link Frequency
HeLa 1
fibroblasts 1
Fgf4 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 12 24.52 Low Low
Inflammation 24 18.72 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
halothane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 16 93.28 High High
Injury 196 92.88 High High
Cytomegalovirus Infection 28 86.12 High High
Diabetes Mellitus 204 81.96 Quite High
Breast Cancer 4 77.20 Quite High
Kaposis Sarcoma 4 76.44 Quite High
Stomach Cancer 4 75.80 Quite High
Wound Healing 68 63.72 Quite High
Pathologic Processes 4 61.56 Quite High
INFLAMMATION 24 18.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The experiments revealed that both VEGF-A and FGF-4 were released from the cells (data not shown) what confirmed previously published observations [21].


Localization (released) of FGF-4
1) Confidence 0.68 Published 2010 Journal Genet Vaccines Ther Section Body Doc Link PMC2939607 Disease Relevance 0.52 Pain Relevance 0
Unlike FGF-1, -2, and -9, which lack a signal peptide (but may still be released by an alternative secretion pathway), FGF4 is efficiently secreted [21], what is rather advantageous over the other FGFs for the gene therapy.
Localization (secreted) of FGF4
2) Confidence 0.68 Published 2010 Journal Genet Vaccines Ther Section Body Doc Link PMC2939607 Disease Relevance 0.43 Pain Relevance 0
In our hands, control (non-transduced and AAV-LacZ-transduced) HeLa cells also did not release FGF4 into the cell culture media (Figure 1d), while they release about 2616 ± 48 pg ml-1 of human VEGF-A (Figure 1c).
Localization (release) of FGF4 in HeLa
3) Confidence 0.68 Published 2010 Journal Genet Vaccines Ther Section Body Doc Link PMC2939607 Disease Relevance 0.15 Pain Relevance 0
Proliferation of db/db fibroblasts cultured in low glucose in the presence of rhFGF4 was slightly weaker than of WT cells and, although the trend was clearly visible, did not reach the statistical significance (103.5 ± 6.3% vs 81.5 ± 7.4% db/db 5.5 mM control, p = 0.09) (Figure 7a).
Localization (presence) of rhFGF4 in fibroblasts
4) Confidence 0.59 Published 2010 Journal Genet Vaccines Ther Section Body Doc Link PMC2939607 Disease Relevance 0.28 Pain Relevance 0

General Comments

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