INT33170

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Context Info
Confidence 0.48
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.58
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm1) plasma membrane (Chrm1) signal transducer activity (Chrm1)
Anatomy Link Frequency
NG108-15 1
brain stem 1
cortex 1
hippocampus 1
Chrm1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 12 100.00 Very High Very High Very High
antidepressant 5 99.90 Very High Very High Very High
Opioid 3 99.68 Very High Very High Very High
agonist 24 99.56 Very High Very High Very High
Endep 6 97.64 Very High Very High Very High
Hippocampus 20 94.72 High High
Delta opioid receptors 1 91.88 High High
Neurotransmitter 10 91.40 High High
Physical dependence 1 88.00 High High
tolerance 1 87.00 High High
Disease Link Frequency Relevance Heat
Disease 123 98.92 Very High Very High Very High
Anxiety Disorder 5 98.68 Very High Very High Very High
Drug Dependence 1 88.00 High High
Poisoning 25 86.56 High High
Convulsion 7 85.28 High High
Drug Induced Neurotoxicity 118 81.88 Quite High
Toxicity 42 81.20 Quite High
Proteostasis Deficiencies 1 80.04 Quite High
Bordatella Infection 1 74.16 Quite High
Intellectual Impairment 4 73.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At micromolar concentrations, compounds 1, 12, and 13 inhibited the binding of [3H]-pirenzepine and of [3H]-di-o-tolylguanidine respectively on M1 and sigma receptors; in the last case comp. 13 was more active (IC50 = 0.3 microM) than the epimeric 1.
M1 Binding (binding) of
1) Confidence 0.48 Published 1996 Journal Farmaco Section Abstract Doc Link 8688138 Disease Relevance 0.09 Pain Relevance 0.07
Ligand interactions with the membrane-bound muscarinic acetylcholine receptor in porcine atria are characterized by using [3H]quinuclidinyl benzilate [Yamamura, H.
muscarinic acetylcholine receptor Binding (interactions) of
2) Confidence 0.35 Published 1980 Journal Biochemistry Section Abstract Doc Link 7407049 Disease Relevance 0 Pain Relevance 0.16
Infralimbic kappa opioid and muscarinic M1 receptor interactions in the concurrent modulation of anxiety and memory.
M1 receptor Binding (interactions) of associated with anxiety disorder and opioid
3) Confidence 0.21 Published 2002 Journal Psychopharmacology (Berl.) Section Title Doc Link 11889492 Disease Relevance 0.28 Pain Relevance 0.24
This compound is an allosteric agonist exhibiting >100-fold specificity for M1 over other mAChR subtypes.
M1 Binding (specificity) of associated with agonist
4) Confidence 0.21 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.34
Comparing all studied antidepressants for muscarinic acetylcholine receptor binding, amitriptylinoxide had the weakest affinity of all tested tricyclic compounds.
muscarinic acetylcholine receptor Binding (binding) of associated with antidepressant
5) Confidence 0.20 Published 1985 Journal Pharmacopsychiatry Section Abstract Doc Link 2996040 Disease Relevance 0 Pain Relevance 0.49
Muscarinic acetylcholine receptor (m2 mAChR) ligand binding with [(3)H]AFDX-384 in cortex and brain stem showed significant increases (approximately 120-130% of control) following coexposure to PB and sarin at higher doses.
Muscarinic acetylcholine receptor Binding (binding) of in brain stem
6) Confidence 0.05 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11861982 Disease Relevance 0.08 Pain Relevance 0
Here we report that long-term (2 days) treatment of NG108-15 cells with ethanol increased the binding of the alpha 2-adrenergic receptor (alpha 2AR) antagonist [3H]rauwolscine and the muscarinic acetylcholine receptor (mAChR) antagonist [3H]quinuclidinyl benzilate by 2.8- and 1.4-fold, respectively.
muscarinic acetylcholine receptor Binding (binding) of in NG108-15 associated with antagonist
7) Confidence 0.05 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8226869 Disease Relevance 0.25 Pain Relevance 0.39
In addition, the binding of ACh to its muscarinergic m1 and m3 receptors can then stimulate the formation of soluble APP (sAPP). sAPP in turn can then modulate synaptic plasticity in the hippocampus and promotes dendritic outgrowth [32].
m1 Binding (binding) of in hippocampus associated with hippocampus
8) Confidence 0.04 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.52 Pain Relevance 0.16
These mice exhibit changes in density of muscarinic acetylcholine receptor (mAChR) binding for as long as 5 months after cessation of exposure [88].
muscarinic acetylcholine receptor Binding (binding) of
9) Confidence 0.04 Published 2008 Journal Environ Health Section Body Doc Link PMC2577708 Disease Relevance 0.29 Pain Relevance 0.16
Eriksson’s group (Ahlbom et al. 1994; Eriksson and Fredriksson 1991; Eriksson et al. 1993; Eriksson and Nordberg 1990) has reported that mice exposed to pyrethroids during PND10–16 exhibit increased motor activity and lack of habituation, as well as changes in density of muscarinic acetylcholine receptor (mAChR) binding for as long as 5 months (Talts et al. 1998) after cessation of exposure.
muscarinic acetylcholine receptor Binding (binding) of
10) Confidence 0.04 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1277854 Disease Relevance 0 Pain Relevance 0.07
Muscarinic acetylcholine receptor (m2 mAChR) ligand binding with [(3)H]AFDX-384 in cortex and brain stem showed significant increases (approximately 120-130% of control) following coexposure to PB and sarin at higher doses.
Muscarinic acetylcholine receptor Binding (binding) of in cortex
11) Confidence 0.02 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11861982 Disease Relevance 0.08 Pain Relevance 0

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