INT331744

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.86
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Fat1) nucleus (Fat1)
Anatomy Link Frequency
fat 9
body 2
Fat1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 4 53.52 Quite High
Central nervous system 9 29.24 Quite Low
anesthesia 24 27.28 Quite Low
ketamine 2 16.96 Low Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 18 99.74 Very High Very High Very High
Body Weight 271 99.66 Very High Very High Very High
Obesity 229 99.58 Very High Very High Very High
Hyperphagia 54 99.46 Very High Very High Very High
Weight Gain 18 97.32 Very High Very High Very High
Appetite Loss 36 96.36 Very High Very High Very High
Abdominal Obesity 11 91.52 High High
Hyperinsulinism 36 84.48 Quite High
Cardiovascular Disease 13 83.40 Quite High
Peripheral Arterial Disease 2 78.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These animals displayed hyperphagia, hypertension and greater fat accumulation (although without showing higher body weight) compared with their controls, and these alterations were further increased with advanced age and were amplified by hypercaloric nutrition.
Positive_regulation (accumulation) of fat in body associated with hyperphagia, body weight and hypertension
1) Confidence 0.15 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 1.00 Pain Relevance 0
However, female animals seem to be protected against the accumulation of excess fat, at least when they are under NF diet, and partially later on, when animals were 5 months old and exposed to HF diet.
Positive_regulation (accumulation) of fat in fat
2) Confidence 0.15 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.25 Pain Relevance 0
As aforementioned, the accumulation of intra-abdominal fat can be measured by direct weighing of fat after dissection.
Positive_regulation (accumulation) of fat in fat
3) Confidence 0.12 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC3014952 Disease Relevance 0.49 Pain Relevance 0.03
On the other hand, it must be also pointed out that the increased leptinemia occurring in CR male animals at the age of 5 months compared with controls could also be reflecting the difference in adiposity, but considering that leptin resistance is today recognized as a significant contributor to obesity [21], the excess of fat accumulation would appear to be more a consequence rather a cause of the hyperleptinemia.
Positive_regulation (accumulation) of fat in fat associated with obesity
4) Confidence 0.11 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.59 Pain Relevance 0
In male animals, this results in higher body weight gain and higher fat accumulation in adulthood.
Positive_regulation (accumulation) of fat in fat associated with body weight
5) Confidence 0.11 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.25 Pain Relevance 0
At the age of 5 months, CR male animals presented higher percentage of body fat than controls (Student's t test) (Figure 1B).
Positive_regulation (percentage) of fat in body
6) Confidence 0.11 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.25 Pain Relevance 0
The reasons for the differences between males and females regarding circulating leptin levels and fat accumulation in adult life due to these particular prenatal conditions are not clearly elucidated yet.
Positive_regulation (accumulation) of fat in fat
7) Confidence 0.11 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.06 Pain Relevance 0
On the other hand, maternal protein restriction during fetal life is associated with an obesogenic phenotype in adulthood and causes an increase of fat food preferences [37].
Positive_regulation (increase) of fat in fat
8) Confidence 0.11 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.31 Pain Relevance 0
However, female animals seem to be protected against the accumulation of excess fat, at least when they are under NF diet, and partially later on, when animals were 5 months old and exposed to HF diet.
Positive_regulation (excess) of fat in fat
9) Confidence 0.10 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.25 Pain Relevance 0
In males, the intrauterine malnutrition resulted in an impairment of normal weight gain and fat deposition from 1 to 53 days of age, in spite of normal food intake; in contrast, in females, this treatment led to a marked fat accumulation by 53 days of age, with normal food intake.
Positive_regulation (accumulation) of fat in fat associated with appetite loss and weight gain
10) Confidence 0.10 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 1.21 Pain Relevance 0
Among the group of 29 rats, 14 rats were previously fed with a normal diet (lean group) and 15 rats were given a high fat/high sucrose diet (fat group) for four months to increase fat mass storage.
Positive_regulation (increase) of fat in fat
11) Confidence 0.08 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC3014952 Disease Relevance 0.21 Pain Relevance 0

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