INT331788

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.15
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
Anatomy Link Frequency
lungs 3
alveolar macrophages 1
gr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 48 79.68 Quite High
Inflammation 110 70.88 Quite High
dexamethasone 2 69.52 Quite High
cINOD 6 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 20 96.38 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 216 95.94 Very High Very High Very High
Disease 66 85.36 High High
INFLAMMATION 164 79.32 Quite High
Asthma 22 73.68 Quite High
Stress 30 7.36 Low Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low
Bronchitis 8 5.00 Very Low Very Low Very Low
Pneumonia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of p38 mitogen-activated protein kinase (MAPK) is elevated in the peripheral lungs and alveolar macrophages in patients with mild or moderate COPD compared with smokers.90 This study also suggested an inverse correlation between the activation of p38 MAPK and the reduction in FEV1 and FEV1/FVC.90 An elevation of p38 MAPK may be responsible for an increase in phosphorylation of GR?
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GR in lungs associated with nicotine addiction and chronic obstructive pulmonary disease
1) Confidence 0.09 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.08 Pain Relevance 0.11
The expression of p38 mitogen-activated protein kinase (MAPK) is elevated in the peripheral lungs and alveolar macrophages in patients with mild or moderate COPD compared with smokers.90 This study also suggested an inverse correlation between the activation of p38 MAPK and the reduction in FEV1 and FEV1/FVC.90 An elevation of p38 MAPK may be responsible for an increase in phosphorylation of GR?
Positive_regulation (increase) of in alveolar macrophages Phosphorylation (phosphorylation) of GR in lungs associated with nicotine addiction and chronic obstructive pulmonary disease
2) Confidence 0.03 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.08 Pain Relevance 0.11

General Comments

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