INT331877

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F8) oxidoreductase activity (F8) extracellular region (F8)
endoplasmic reticulum (Mest) cell adhesion (F8) plasma membrane (F8)
Anatomy Link Frequency
platelets 1
vein 1
F8 (Homo sapiens)
Mest (Mus musculus)
Pain Link Frequency Relevance Heat
cva 12 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 196 99.60 Very High Very High Very High
Hemorrhage 80 70.32 Quite High
Injury 24 10.80 Low Low
Factor Viii Deficiency 12 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Thrombosis 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FVIII binds PEGLip specifically and with high affinity (two binding sites, KD of 4.5 and 1.9 nM), but this interaction does not alter FVIII activity, as shown by maintenance of full activity after formulation.45,46 The association of FVIII with PEGLip does not affect the FVIII protein’s structure.
FVIII Binding (association) of PEG
1) Confidence 0.49 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2939703 Disease Relevance 0 Pain Relevance 0
FVIII binds PEGLip specifically and with high affinity (two binding sites, KD of 4.5 and 1.9 nM), but this interaction does not alter FVIII activity, as shown by maintenance of full activity after formulation.45,46 The association of FVIII with PEGLip does not affect the FVIII protein’s structure.
FVIII Binding (binds) of PEG
2) Confidence 0.49 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2939703 Disease Relevance 0 Pain Relevance 0
Having shown that PEGLip bind FVIII and FVIIa45,47 and that PEGLip bind platelets, we next tested whether PEGLip are capable of delivering proteins to platelets.
FVIII Binding (bind) of PEG in platelets
3) Confidence 0.38 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2939703 Disease Relevance 0.07 Pain Relevance 0
Mice that received PEGLip-FVIII bled less and survived significantly longer (P < 0.05) than mice that received standard FVIII or saline (Figure 2A).45,46 This significantly increased survival of tail-vein transected hemophilic mice following the injection of PEGip formulated recombinant FVIII was also demonstrated by others.50 The increased survival rate was dependent on the pre-formation of a complex of FVIII and PEGLip.
FVIII Binding (complex) of PEG in vein
4) Confidence 0.37 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2939703 Disease Relevance 0.34 Pain Relevance 0

General Comments

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