INT331886

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 2.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

helicase activity (DDX4) cytoplasm (DDX4)
Anatomy Link Frequency
germ cells 5
testes 3
DDX4 (Homo sapiens)
Pain Link Frequency Relevance Heat
analgesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma In Situ 36 95.22 Very High Very High Very High
Congenital Anomalies 45 88.56 High High
Syndrome 99 87.68 High High
Malignant Neoplastic Disease 9 87.32 High High
Testicular Cancer 18 85.48 High High
Cryptorchidism 9 83.68 Quite High
Hypospadias 9 82.08 Quite High
Oligospermia 9 80.80 Quite High
Hypertrophy 9 59.16 Quite High
Hyperplasia 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gonocyte pluripotency marker OCT4 was expressed in most germ cells of first trimester testes prior to grafting, while after grafting some of the germ cells had ceased to express this protein, coincident with emerging expression of proteins associated with differentiation into pre-spermatogonia, such as MAGE-A4 and VASA (Fig. 4A).
Gene_expression (express) of VASA in testes
1) Confidence 0.12 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0.06 Pain Relevance 0
Further evidence for normal germ cell differentiation after grafting is that the % of cells expressing OCT4 or VASA in xenografts was not significantly different from that found in equivalent age-matched controls (Fig. 4B).
Gene_expression (expressing) of VASA in germ cell
2) Confidence 0.10 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
The % of cells expressing OCT4 after grafting was significantly reduced when compared with the pre-graft control tissue for both first and second trimester testes, while the % of cells expressing VASA significantly increased in the first-trimester grafts, compared with the pre-graft control.
Gene_expression (expressing) of VASA in testes
3) Confidence 0.10 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
The proportion of germ cells expressing OCT4 (red bars) or VASA (blue bars) in first (upper panels) and second (lower panels) trimester human fetal testes for pre-graft control, grafts and equivalent non-grafted controls.
Gene_expression (expressing) of VASA in germ cells
4) Confidence 0.10 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
The results confirmed that the % of cells expressing OCT4 decreased during the grafting period while the % of cells expressing VASA increased.
Gene_expression (expressing) of VASA
5) Confidence 0.10 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
The gonocyte pluripotency marker OCT4 was expressed in most germ cells of first trimester testes prior to grafting, while after grafting some of the germ cells had ceased to express this protein, coincident with emerging expression of proteins associated with differentiation into pre-spermatogonia, such as MAGE-A4 and VASA (Fig. 4A).
Gene_expression (expression) of VASA in testes
6) Confidence 0.09 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0.06 Pain Relevance 0
CIS cells are thought to originate because of failure of normal differentiation of fetal germ cells into prespermatogonia (Rajpert-De Meyts, 2006), a process that encompasses fetal and early post-natal life in humans and involves the loss of expression of pluripotency factors (OCT4 and NANOG) and expression of proteins indicative of differentiation (VASA and MAGE-A4) (Gaskell et al., 2004; Anderson et al., 2007; Mitchell et al., 2008).
Gene_expression (expression) of VASA in germ cells associated with carcinoma in situ
7) Confidence 0.08 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 1.14 Pain Relevance 0
Note that after grafting, the proportion of germ cells expressing OCT4 decreases as demonstrated by the presence of unstained germ cells (arrowhead), compared with the pre-graft control, whereas expression of MAGE-A4 and VASA (arrows, inset) increase (neither are expressed in the pre-graft control).
Gene_expression (expression) of VASA in germ cells
8) Confidence 0.08 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
CIS cells are thought to originate because of failure of normal differentiation of fetal germ cells into prespermatogonia (Rajpert-De Meyts, 2006), a process that encompasses fetal and early post-natal life in humans and involves the loss of expression of pluripotency factors (OCT4 and NANOG) and expression of proteins indicative of differentiation (VASA and MAGE-A4) (Gaskell et al., 2004; Anderson et al., 2007; Mitchell et al., 2008).
Gene_expression (expression) of VASA in germ cells associated with carcinoma in situ
9) Confidence 0.08 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 1.13 Pain Relevance 0

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