INT331888

Context Info Confidence 0.13 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0 Pain Relevance 0

molecular_function (MAGEA4) cellular_component (MAGEA4) biological_process (MAGEA4)

Anatomy Link Frequency germ cells 2 Sertoli cells 1 MAGEA4 (Homo sapiens)

Pain Link Frequency Relevance Heat analgesia 3 5.00

Disease Link Frequency Relevance Heat Hyperplasia 3 47.04 Syndrome 33 5.00 Congenital Anomalies 15 5.00 Carcinoma In Situ 12 5.00 Testicular Cancer 6 5.00 Cryptorchidism 3 5.00 Spontaneous Abortion 3 5.00 Targeted Disruption 3 5.00 Hypertrophy 3 5.00 Dislocations 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This demonstrated that a proportion of all three subpopulations of germ cells (OCT4+/MAGE-A4?

Positive_regulation (subpopulations) of MAGE-A4 in germ cells

1) Confidence 0.13 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0

The cells stained for Ki67 that are negative for OCT4 and MAGE-A4 represent proliferating Sertoli cells (orange arrowhead).

Positive_regulation (negative) of MAGE-A4 in Sertoli cells

2) Confidence 0.13 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0

Note that after grafting, the proportion of germ cells expressing OCT4 decreases as demonstrated by the presence of unstained germ cells (arrowhead), compared with the pre-graft control, whereas expression of MAGE-A4 and VASA (arrows, inset) increase (neither are expressed in the pre-graft control).

Neg (neither) Positive_regulation (increase) of MAGE-A4 in germ cells

3) Confidence 0.11 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.