INT331921

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.43
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Fig4) endosome (Fig4) cell death (Fig4)
Golgi apparatus (Fig4) endoplasmic reticulum (Fig4)
Anatomy Link Frequency
peritoneal macrophages 1
Fig4 (Mus musculus)
Pain Link Frequency Relevance Heat
diclofenac 190 99.00 Very High Very High Very High
Inflammation 18 5.00 Very Low Very Low Very Low
COX-2 inhibitor 12 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 250 99.56 Very High Very High Very High
Pancreatic Cancer 26 76.64 Quite High
Injury 4 55.68 Quite High
Apoptosis 22 42.40 Quite Low
Esophageal Cancer 2 28.16 Quite Low
Non-genital Cutaneous Warts 2 15.60 Low Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Metastasis 8 5.00 Very Low Very Low Very Low
Pancreatitis 8 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike the clear antineoplastic effect of diclofenac through inhibition of angiogenesis, the striking activation of arginase activity (Fig 4), both in tumor stroma and in peritoneal macrophages is difficult to assess in context of pro- or anti-cancer activity.
Positive_regulation (activation) of Fig 4 in peritoneal macrophages associated with cancer and diclofenac
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939880 Disease Relevance 0.92 Pain Relevance 0.08
The arginase protein level per equal number of cells was increased 2 fold Fig S4.
Positive_regulation (increased) of Fig S4
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939880 Disease Relevance 0.51 Pain Relevance 0.30

General Comments

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