INT331923

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.99
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
T-cell 1
Actvty1 (Mus musculus)
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
diclofenac 95 83.44 Quite High
Inflammation 9 5.00 Very Low Very Low Very Low
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 125 100.00 Very High Very High Very High
Pancreatic Cancer 13 50.00 Quite Low
Non-genital Cutaneous Warts 1 44.64 Quite Low
Apoptosis 11 27.84 Quite Low
Esophageal Cancer 1 13.60 Low Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low
Pancreatitis 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors proposed that high COX-2 activity of tumor cells releases PGE2, which activates arginase in MDSC and leads to extracellular arginine depletion and subsequent T-cell dysfunction.
activity Positive_regulation (releases) of PGE2 in T-cell associated with cancer
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939880 Disease Relevance 0.99 Pain Relevance 0.04

General Comments

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