INT331927

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.80
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Arg1) signal transduction (Ptger2) plasma membrane (Ptger2)
cytoplasm (Arg1) signal transducer activity (Ptger2)
Anatomy Link Frequency
T-cell 1
Ptger2 (Mus musculus)
Arg1 (Mus musculus)
Pain Link Frequency Relevance Heat
diclofenac 190 88.48 High High
COX-2 inhibitor 12 80.56 Quite High
Inflammation 18 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 250 99.68 Very High Very High Very High
Pancreatic Cancer 26 90.44 High High
Non-genital Cutaneous Warts 2 46.72 Quite Low
Apoptosis 22 26.52 Quite Low
Esophageal Cancer 2 12.28 Low Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Metastasis 8 5.00 Very Low Very Low Very Low
Pancreatitis 8 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Adenocarcinoma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors proposed that high COX-2 activity of tumor cells releases PGE2, which activates arginase in MDSC and leads to extracellular arginine depletion and subsequent T-cell dysfunction.
PGE2 Positive_regulation (activates) of arginase in T-cell associated with cancer
1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939880 Disease Relevance 1.04 Pain Relevance 0.04
PGE2 induces arginase 1 activity and arginine uptake in myeloid derived suppressor cells (MDSCs), thus causing arginine depletion in the tumor surrounding.
PGE2 Positive_regulation (induces) of arginase 1 associated with cancer
2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939880 Disease Relevance 0.77 Pain Relevance 0.37

General Comments

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