INT331991

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.75 Pain Relevance 0.31

extracellular space (LEFTY2) extracellular region (LEFTY2)

Anatomy Link Frequency extracellular matrix 1 LEFTY2 (Homo sapiens)

Pain Link Frequency Relevance Heat cva 34 98.52 Arachnoiditis 1 97.68 Inflammation 1 86.16

Disease Link Frequency Relevance Heat Cv General 3 Under Development 28 98.52 Arachnoiditis 1 97.68 Hydrocephalus 11 96.74 Hematoma 67 91.52 Pressure And Volume Under Development 2 86.60 INFLAMMATION 1 86.16 Infection 4 74.32 Hemorrhage 3 49.12 Injury 4 20.72 Adhesions 1 19.12

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Posthemorrhagic communicating hydrocephalus is usually ascribed to fibrosing arachnoiditis, which has been suggested to be caused by the increased deposition of extracellular matrix proteins because of the upregulation of transforming growth factor-beta (TGF-beta).[6] In order to maintain ICP, the patient’s stay in the intensive care unit is to be shortened,[13] the communicating hydrocephalus is prevented,[25] and the control of acute hydrocephalus and EVD of IVH is essential.

Positive_regulation (upregulation) of transforming growth factor-beta in extracellular matrix associated with arachnoiditis, hematoma, hydrocephalus and cva

1) Confidence 0.03 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC2940103 Disease Relevance 1.75 Pain Relevance 0.31

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