INT332001

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.15
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3ar1) plasma membrane (C3ar1) signal transducer activity (C3ar1)
Anatomy Link Frequency
cleavage 1
heart 1
C3ar1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 60 98.72 Very High Very High Very High
Inflammation 36 95.52 Very High Very High Very High
antagonist 15 67.36 Quite High
Inflammatory response 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 21 99.16 Very High Very High Very High
Reperfusion Injury 3 98.20 Very High Very High Very High
Cardiovascular Disease 3 97.72 Very High Very High Very High
INFLAMMATION 36 95.52 Very High Very High Very High
Death 12 95.08 Very High Very High Very High
Injury 111 91.68 High High
Cv Unclassified Under Development 48 75.60 Quite High
Myocardial Infarction 18 74.00 Quite High
Stroke 6 68.40 Quite High
Neutropenia 27 65.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anaphylatoxins C3a and C5a are not initiating factors of the complement system, but they appear to be responsible for promoting, amplifying and perpetuating inflammatory reactions [3], [4], [38].
C3a Binding (initiating) of associated with inflammation
1) Confidence 0.28 Published 2010 Journal GMS German Medical Science Section Body Doc Link PMC2940219 Disease Relevance 0.75 Pain Relevance 0.09
Role of the complement components C5 and C3a in a mouse model of myocardial ischemia and reperfusion injury

Objective: Ischemic heart disease is the leading cause of death worldwide.

C3a Binding (complement) of in heart associated with reperfusion injury, coronary artery disease, ischemia and death
2) Confidence 0.25 Published 2010 Journal GMS German Medical Science Section Title Doc Link PMC2940219 Disease Relevance 1.11 Pain Relevance 0.21
Each C3 convertase cleaves C3 into two fragments, the anaphylotoxin C3a and the complement component C3b, which binds to the C3 convertase to form a C5 convertase, followed by cleavage of C5 into C5a and C5b [3], [4].
C3a Binding (binds) of in cleavage
3) Confidence 0.24 Published 2010 Journal GMS German Medical Science Section Body Doc Link PMC2940219 Disease Relevance 0.29 Pain Relevance 0.09

General Comments

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