INT332007

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.99
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3ar1) plasma membrane (C3ar1) signal transducer activity (C3ar1)
C3ar1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 40 97.04 Very High Very High Very High
antagonist 10 95.60 Very High Very High Very High
Inflammation 24 80.16 Quite High
Inflammatory response 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 32 97.04 Very High Very High Very High
Injury 74 94.44 High High
Neutropenia 18 88.00 High High
Coronary Artery Disease 14 82.08 Quite High
INFLAMMATION 24 80.16 Quite High
Death 8 77.44 Quite High
Reperfusion Injury 2 74.84 Quite High
Myocarditis 4 53.28 Quite High
Myocardial Infarction 12 5.00 Very Low Very Low Very Low
Stroke 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systemic C5 or C3a inhibition was performed with an anti-C5 monoclonal antibody (BB5.1) 30 min prior to reperfusion or with a C3a receptor antagonist (C3aRA).
Negative_regulation (inhibition) of C3a associated with antagonist
1) Confidence 0.39 Published 2010 Journal GMS German Medical Science Section Abstract Doc Link PMC2940219 Disease Relevance 1.18 Pain Relevance 0.24
While C5 inhibition in the clinical setting of MI/R does not appear to be therapeutic, our results raise the possibility that inhibition of either C5a or C5b-9 may be more advantageous than inhibition of C3a or complete inhibition of C5 in humans.



Negative_regulation (inhibition) of C3a
2) Confidence 0.29 Published 2010 Journal GMS German Medical Science Section Abstract Doc Link PMC2940219 Disease Relevance 0.81 Pain Relevance 0.06

General Comments

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