INT332038

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 1.35
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (kita) plasma membrane (kita) nucleus (tfap2a)
kinase activity (kita)
Anatomy Mention Frequency
melanocyte 6
tfap2a (Danio rerio)
kita (Danio rerio)
Pain Term Frequency Confidence Heat
addiction 5 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 5 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
Central nervous system 20 5.00 Very Low Very Low Very Low
dexamethasone 15 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Skin Cancer 35 98.88 Very High Very High Very High
Microphthalmia 55 93.76 High High
Disease 10 92.76 High High
Congenital Anomalies 5 88.52 High High
Hypopigmentation 5 77.36 Quite High
Apoptosis 25 71.36 Quite High
Toxicity 20 5.00 Very Low Very Low Very Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Death 55 5.00 Very Low Very Low Very Low
Fibromyalgia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this model, Transcription Factor Activator Protein 2 alpha (TFAP2A) contributes to melanocyte development by activating expression of the gene encoding the receptor tyrosine kinase Kit.
Transcription Factor Activator Protein 2 alpha Positive_regulation (activating) of Gene_expression (expression) of Kit in melanocyte
1) Confidence 0.63 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2940735 Disease Relevance 0.29 Pain Relevance 0
In this model, Transcription Factor Activator Protein 2 alpha (TFAP2A) contributes to melanocyte development by activating expression of the gene encoding the receptor tyrosine kinase Kit.
TFAP2A Positive_regulation (activating) of Gene_expression (expression) of Kit in melanocyte
2) Confidence 0.63 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2940735 Disease Relevance 0.28 Pain Relevance 0
Because many Tfap2 family members have the same DNA binding affinity, it is possible that another such family member cooperates with Tfap2a to activate Kit expression.
Tfap2a Positive_regulation (activate) of Gene_expression (expression) of Kit
3) Confidence 0.48 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2940735 Disease Relevance 0.07 Pain Relevance 0
Because many Tfap2 family members have identical DNA┬ľbinding specificity, we reasoned that another Tfap2 family member may work redundantly with Tfap2a in promoting Kit expression.
Tfap2a Positive_regulation (promoting) of Gene_expression (expression) of Kit
4) Confidence 0.42 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2940735 Disease Relevance 0.21 Pain Relevance 0
We provide evidence that Tfap2e cooperates with Tfap2a to promote expression of zebrafish kita in embryonic melanocytes.
Tfap2a Positive_regulation (promote) of Gene_expression (expression) of kita in melanocytes
5) Confidence 0.42 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2940735 Disease Relevance 0.50 Pain Relevance 0

General Comments

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