INT33209

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Context Info
Confidence 0.68
First Reported 1985
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 0.63
Pain Relevance 8.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
neuronal 2
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 850 100.00 Very High Very High Very High
opiate 12 100.00 Very High Very High Very High
mu opioid receptor 7 100.00 Very High Very High Very High
Opioid receptor 1 1 100.00 Very High Very High Very High
Morphine 23 99.58 Very High Very High Very High
cocaine 20 99.20 Very High Very High Very High
Analgesic 84 99.18 Very High Very High Very High
agonist 68 97.20 Very High Very High Very High
Enkephalin 34 96.90 Very High Very High Very High
antagonist 211 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Glioma 2 94.40 High High
Neuroblastoma 2 94.04 High High
Bordatella Infection 2 87.68 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

75 76.44 Quite High
Pheochromocytoma 26 54.48 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

160 34.20 Quite Low
Nociception 35 33.60 Quite Low
Pain 55 5.00 Very Low Very Low Very Low
Alcohol Addiction 12 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The upregulation of mu opioid receptor binding persisted after 4 weeks of monitored cocaine abstinence.
Positive_regulation (upregulation) of mu opioid receptor Binding (binding) of associated with mu opioid receptor and cocaine
1) Confidence 0.68 Published 1996 Journal Nat. Med. Section Abstract Doc Link 8898749 Disease Relevance 0 Pain Relevance 0.92
Increased mu opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving.
Positive_regulation (Increased) of mu opioid receptor Binding (binding) of associated with mu opioid receptor and cocaine
2) Confidence 0.68 Published 1996 Journal Nat. Med. Section Title Doc Link 8898749 Disease Relevance 0 Pain Relevance 0.88
To better understand structural requirements for a mu ligand of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class to interact with the mu opioid receptor, we have described in the previous article (Le Bourdonnec, B. et al.
Positive_regulation (requirements) of mu opioid receptor Binding (interact) of associated with mu opioid receptor
3) Confidence 0.50 Published 2006 Journal J. Med. Chem. Section Abstract Doc Link 17149859 Disease Relevance 0 Pain Relevance 0.35
It has been shown that [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAMGO), a potent MOR agonist inducing the internalization, facilitates morphine to internalize MOR, suggesting that MOR agonists with low relative activity versus endocytosis (RAVE) values such as DAMGO can potentiate analgesic effects of morphine through stimulating MOR internalization.
Positive_regulation (stimulating) of MOR Binding (internalization) of associated with analgesic, agonist, opioid receptor, enkephalin and morphine
4) Confidence 0.44 Published 2006 Journal Anesthesiology Section Abstract Doc Link 16931992 Disease Relevance 0 Pain Relevance 1.59
Ethanol also induces MOP internalization; however the time course of ethanol-induced MOP internalization is complex and markedly different from the course of ligand-induced internalization (Fig. 1D).
Positive_regulation (induces) of MOP Binding (internalization) of associated with opioid receptor
5) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2602977 Disease Relevance 0 Pain Relevance 0.76
Ethanol also induces MOP internalization; however the time course of ethanol-induced MOP internalization is complex and markedly different from the course of ligand-induced internalization (Fig. 1D).
Positive_regulation (induced) of MOP Binding (internalization) of associated with opioid receptor
6) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2602977 Disease Relevance 0.05 Pain Relevance 0.76
Beta-casomorphins: substitution of phenylalanine with beta-homo phenylalanine increases the mu-type opioid receptor affinity.
Positive_regulation (increases) of mu-type opioid receptor Binding (affinity) of associated with opioid receptor 1
7) Confidence 0.39 Published 2000 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 10866377 Disease Relevance 0 Pain Relevance 0.15
MOR internalization induced by H2S is mediated by its recruitment to a protein-protein complex with ?
Positive_regulation (mediated) of MOR Binding (internalization) of associated with opioid receptor
8) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.61
The fact that inhibition of AKT phosphorylation by the PI3K inhibitor LY294002 prevents MOR internalization induced by H2S but not by DAMGO, indicates that H2S directly activates the PI3K/AKT pathway and that activation of this pathway is hierarchically higher in the mechanism that leads to MOR activation by H2S.
Neg (not) Positive_regulation (induced) of MOR Binding (internalization) of associated with opioid receptor
9) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.38
MOR internalization induced by H2S is mediated by its recruitment to a protein-protein complex with ?
Positive_regulation (induced) of MOR Binding (internalization) of associated with opioid receptor
10) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.61
receptor-selective enkephalin analog DAMGO and H2S confirm these data demonstrating that, in the neuronal-cell line SKNMC, both DAMGO and H2S induce MOR activation and phosphorylation leading to interaction between MOR and ?
Positive_regulation (leading) of MOR Binding (interaction) of in neuronal associated with opioid receptor and enkephalin
11) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 1.11
By co-immunoprecipitation experiments (Figure 5, panel E) we found that exposure of SKNMCs to DAMGO and Na2S caused a robust induction of MOR association with ?
Positive_regulation (induction) of MOR Binding (association) of associated with opioid receptor
12) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.48
Whether opiate receptor internalization requires the activation of the guanine nucleotide-binding protein (Ni) is unclear.
Spec (Whether) Positive_regulation (requires) of opiate receptor Spec (Whether) Binding (internalization) of associated with opiate
13) Confidence 0.01 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2997225 Disease Relevance 0.50 Pain Relevance 0.37

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