INT3321

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Context Info
Confidence 0.51
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.08
Pain Relevance 0.32

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mitochondrion (ALAS2) small molecule metabolic process (ALAS2) biosynthetic process (ALAS2)
transferase activity, transferring acyl groups (ALAS2)
Anatomy Link Frequency
tubes 1
liver 1
ALAS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 3 99.30 Very High Very High Very High
Pain 17 61.12 Quite High
Glutamate 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sideroblastic Anemia 30 99.20 Very High Very High Very High
Porphyria 16 98.92 Very High Very High Very High
Disease 55 98.52 Very High Very High Very High
Cognitive Disorder 28 96.48 Very High Very High Very High
Hepatic Porphyrias 6 93.36 High High
Iron Overload 49 93.28 High High
Death 52 89.04 High High
Starvation 24 88.32 High High
Ataxia 48 87.72 High High
Targeted Disruption 4 79.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore marked porphyrin accumulation was not seen with many drugs that induce delta-aminolevulinate synthase and cytochrome P-450 but was more characteristic of compounds that reduced the metabolism of protoporphyrin to heme, such as 1,4-dihydro-3,5-dicarbethoxycollidine (DDC) and high doese of hydralazine.
Positive_regulation (induce) of delta-aminolevulinate synthase
1) Confidence 0.51 Published 1978 Journal Biochim. Biophys. Acta Section Abstract Doc Link 708789 Disease Relevance 0.24 Pain Relevance 0.07
Differential effects of these and other drugs were observed in the avian liver, in that delta-aminolevulinate synthase was more commonly induced than were porphyrins and cytochrome P-450; the synthase was usually highest 6-12 h after injection, whereas porphyrins and cytochrome P-450 were highest at 24 h.
Positive_regulation (induced) of delta-aminolevulinate synthase in liver
2) Confidence 0.51 Published 1978 Journal Biochim. Biophys. Acta Section Abstract Doc Link 708789 Disease Relevance 0.23 Pain Relevance 0.09
sulfur cluster biogenesis; it also occurs in other diseases, such as the sideroblastic anemia caused by ALAS2 mutations, even though ALAS2 mediates the first condensation of heme biosynthesis and is not directly involved in Fe?
Positive_regulation (mediates) of ALAS2 associated with porphyria, sideroblastic anemia and disease
3) Confidence 0.43 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.67 Pain Relevance 0
Another well-known XLSA is caused by mutations in the ALAS2 gene which encodes the first enzyme of heme synthesis in erythroid cells.
Positive_regulation (caused) of XLSA
4) Confidence 0.35 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.46 Pain Relevance 0
Hydralazine, pargyline, phenoxybenzamine, clonidine, and spironolactone were found to induce delta-aminolevulinate synthase in this system.
Positive_regulation (induce) of delta-aminolevulinate synthase associated with clonidine
5) Confidence 0.34 Published 1978 Journal Biochim. Biophys. Acta Section Abstract Doc Link 708789 Disease Relevance 0.17 Pain Relevance 0.10
Mutations in ALAS2, SLC25A28 (MFRN2) and SLC11A2 (DMT1) were excluded in previous analyses.
Positive_regulation (Mutations) of ALAS2
6) Confidence 0.23 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.08 Pain Relevance 0
If relatives do not come to an agreement, physicians tend to follow a conservative option, and thus, provide ANH.


Positive_regulation (provide) of ANH
7) Confidence 0.03 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC1997114 Disease Relevance 0.41 Pain Relevance 0
The purpose of this study is to understand why Japanese physicians feel bound to provide ANH, particularly through the use of PEG tubes, to older patients with severe, irreversible cognitive impairment.
Positive_regulation (provide) of ANH in tubes associated with cognitive disorder
8) Confidence 0.03 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC1997114 Disease Relevance 0.32 Pain Relevance 0
Lack of relevant legislation or guidelines that protect physicians when withholding and withdrawing life-prolonging medical treatment in Japan [29] creates a strong incentive for many physicians to provide ANH irrespective of patients' conditions.
Positive_regulation (provide) of ANH
9) Confidence 0.03 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC1997114 Disease Relevance 0.27 Pain Relevance 0.06
The objective of this study was to identify and analyze factors related to the decision to provide ANH through percutaneous endoscopic gastrostomy (PEG) in older Japanese adults with severe cognitive impairment.


Positive_regulation (provide) of ANH associated with cognitive disorder
10) Confidence 0.03 Published 2007 Journal BMC Geriatr Section Abstract Doc Link PMC1997114 Disease Relevance 0.25 Pain Relevance 0

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