INT332159

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.11
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gh, Igfbp3) nucleus (Gh, Igfbp3) cytosol (Gh)
signal transduction (Gh) mitochondrion (Gh) extracellular region (Gh)
Anatomy Link Frequency
spine 3
femur 1
Gh (Mus musculus)
Igfbp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 12 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
Clonidine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
pulpitis 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 24 100.00 Very High Very High Very High
Osteogenesis Imperfecta 224 89.40 High High
Disease 44 35.72 Quite Low
Congenital Anomalies 26 5.00 Very Low Very Low Very Low
Scoliosis 16 5.00 Very Low Very Low Very Low
Hypercalcemia 16 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
Platybasia 10 5.00 Very Low Very Low Very Low
Growth Problems 10 5.00 Very Low Very Low Very Low
Deafness 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GH action positively affects bone growth and bone turnover by stimulating osteoblasts, collagen synthesis and longitudinal bone growth.109 As part from this positive action on bone, GH has a positive action on collagen metabolism, stimulating the expression in osteoblast cultures of IGF-I and IGF binding protein-3, which in turn regulate the synthesis of type I collagen.110,111 Osteoblasts from various species have IGF-I receptors and respond to both endogenous and exogenous IGF by accelerating the proliferation, increasing DNA and collagen synthesis.112,113 On the other hand, animal studies in the mouse model of OI, with bone phenotype comparable to a mild form of OI in humans (oim/+), showed that systemic GH injections114 or GH transgene expression in erythroid marrow115 increased spine and femur length, produced significant changes in densitometric parameters and ameliorated biomechanical structural properties of bone.
GH Positive_regulation (stimulating) of Gene_expression (expression) of IGF binding protein-3 in spine associated with osteogenesis imperfecta and osteoporosis
1) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940745 Disease Relevance 0.55 Pain Relevance 0
GH action positively affects bone growth and bone turnover by stimulating osteoblasts, collagen synthesis and longitudinal bone growth.109 As part from this positive action on bone, GH has a positive action on collagen metabolism, stimulating the expression in osteoblast cultures of IGF-I and IGF binding protein-3, which in turn regulate the synthesis of type I collagen.110,111 Osteoblasts from various species have IGF-I receptors and respond to both endogenous and exogenous IGF by accelerating the proliferation, increasing DNA and collagen synthesis.112,113 On the other hand, animal studies in the mouse model of OI, with bone phenotype comparable to a mild form of OI in humans (oim/+), showed that systemic GH injections114 or GH transgene expression in erythroid marrow115 increased spine and femur length, produced significant changes in densitometric parameters and ameliorated biomechanical structural properties of bone.
GH Positive_regulation (stimulating) of in femur Gene_expression (expression) of IGF binding protein-3 in spine associated with osteogenesis imperfecta and osteoporosis
2) Confidence 0.02 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940745 Disease Relevance 0.55 Pain Relevance 0

General Comments

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