INT332162

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dck) nucleus (Dck) kinase activity (Dck)
Anatomy Link Frequency
Lymphocytes 1
Dck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 2 81.36 Quite High
Central nervous system 5 65.92 Quite High
nud 1 55.44 Quite High
Pain 3 55.00 Quite High
cva 1 52.28 Quite High
Multiple sclerosis 59 50.00 Quite Low
imagery 16 37.60 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
Leflunomide 3 5.00 Very Low Very Low Very Low
Parenteral administration 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphopenia 3 88.24 High High
Central Nervous System Disease 3 65.92 Quite High
Congenital Anomalies 1 57.88 Quite High
Pressure And Volume Under Development 1 56.08 Quite High
Dyspepsia 1 55.44 Quite High
Pain 3 55.00 Quite High
Disease 10 54.04 Quite High
Hemorrhage 1 52.28 Quite High
Pituitary Cancer 1 51.64 Quite High
Budd-chiari Syndrome 1 50.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cladribine prodrug enters cells via purine nucleoside transporters and once within the cell, undergoes initial phosphorylation by deoxycytidine kinase.22 Lymphocytes are particularly susceptible to the effects of cladribine because of their high intracellular ratio of deoxycytidine kinase to 5’-nucleotidase.
Phosphorylation (phosphorylation) of deoxycytidine kinase in Lymphocytes
1) Confidence 0.04 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940747 Disease Relevance 0.59 Pain Relevance 0.22

General Comments

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