INT33220

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Context Info
Confidence 0.58
First Reported 1983
Last Reported 2011
Negated 2
Speculated 4
Reported most in Body
Documents 110
Total Number 118
Disease Relevance 70.21
Pain Relevance 9.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 3
liver 3
ANS 2
heart 2
tail 1
ras (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 34 100.00 Very High Very High Very High
Inflammation 337 99.96 Very High Very High Very High
aspirin 45 99.90 Very High Very High Very High
Catecholamine 5 99.68 Very High Very High Very High
Nicotine 9 99.24 Very High Very High Very High
Enkephalin 2 99.20 Very High Very High Very High
Calcium channel 109 99.12 Very High Very High Very High
agonist 24 99.08 Very High Very High Very High
Morphine 1 99.00 Very High Very High Very High
fibrosis 27 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Canker Sores 81 100.00 Very High Very High Very High
Post-traumatic Stress Disorder 43 100.00 Very High Very High Very High
Pain 30 100.00 Very High Very High Very High
INFLAMMATION 334 99.96 Very High Very High Very High
Apoptosis 205 99.96 Very High Very High Very High
Tinnitus 960 99.92 Very High Very High Very High
Colon Cancer 400 99.84 Very High Very High Very High
Left Ventricular Dysfunction 84 99.84 Very High Very High Very High
Cancer 591 99.56 Very High Very High Very High
Diabetic Retinopathy 40 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of Ras attenuates the course of experimental autoimmune neuritis.
Negative_regulation (Inhibition) of Ras associated with experimental autoimmune neuritis and neuritis
1) Confidence 0.58 Published 2005 Journal J. Neuroimmunol. Section Title Doc Link 16154640 Disease Relevance 0.20 Pain Relevance 0.13
Inhibition of Ras is of potential use in the treatment of inflammatory neuropathies.
Negative_regulation (Inhibition) of Ras associated with inflammation
2) Confidence 0.58 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 16154640 Disease Relevance 0.25 Pain Relevance 0.12
Some researchers thought that this protective effect is related to the increased keratinization of the oral mucosa in smokers and that this keratin layer acts as a mechanical and chemical barrier against trauma or microbes.4,5,10 In contrast, some have hypothesized that nicotine may be the responsible agent for the reduction in RAS prevalence rate in smokers.8 Nicotine has been shown to affect the immune response in inflammatory conditions by inducing the production of adrenal steroids through the hypothalamus– pituitary–adrenal axis and reducing the production of tumor necrosis factor-?
Negative_regulation (reduction) of RAS in pituitary associated with necrosis, nicotine addiction, inflammation, cancer, nicotine, injury and canker sores
3) Confidence 0.50 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999509 Disease Relevance 2.27 Pain Relevance 0.21
Aliskiren was found to inhibit RAS activity in a dose dependent manner, with a maximum reduction in Ang II levels by the first hour after administration of the dose and suppression up to six hours.
Negative_regulation (inhibit) of RAS
4) Confidence 0.49 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.21 Pain Relevance 0.09
Important clinical information on RAS blockade can also be extracted from the ALLHAT study, which evaluated the efficacy of ACE inhibitors over other anti-hypertensives in prevention of cardiovascular events (ALLHAT 2002).
Negative_regulation (blockade) of RAS
5) Confidence 0.49 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.43 Pain Relevance 0.03
The study is scheduled to be completed in 2007 and will provide useful information regarding inhibition of RAS with ARBs in patients with glucose intolerance and metabolic syndrome.
Negative_regulation (inhibition) of RAS associated with metabolic syndrome and impaired glucose tolerance
6) Confidence 0.49 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.35 Pain Relevance 0.15
Whether these agents that inhibit the RAS are useful in all patients with atherosclerosis remains to be seen and will certainly be the topic of future clinical studies.



Negative_regulation (inhibit) of RAS associated with atherosclerosis
7) Confidence 0.49 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.73 Pain Relevance 0.04
AIM: The Glycemic Effect in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) trial compared the metabolic effects of two beta-blockers in people with type 2 diabetes and hypertension treated with renin-angiotensin system (RAS) blockade and found differences in metabolic outcomes.
Negative_regulation (blockade) of RAS associated with beta blocker, diabetes mellitus and hypertension
8) Confidence 0.47 Published 2007 Journal Diabetes Obes Metab Section Abstract Doc Link 17391169 Disease Relevance 0.37 Pain Relevance 0.13
KO mice were evaluated for novelty-induced locomotor activity, responses to open field situations, stress in the elevated plus maze (EPM) and light/dark transition test, social affiliation/novelty, forced swim and tail suspension tests, sensorimotor gating ability by prepulse inhibition of acoustic startle response (PPI/ASR), attention-related processes in the latent inhibition (LI) and learning/memory in the fear conditioning (FC) and passive avoidance paradigms.
Negative_regulation (inhibition) of ASR in tail associated with stress, post-traumatic stress disorder, eae and anxiety disorder
9) Confidence 0.42 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.66 Pain Relevance 0.08
This reaction was weak in groups of rat treated with DBTC and RAS inhibitors.
Negative_regulation (inhibitors) of RAS
10) Confidence 0.41 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18812642 Disease Relevance 1.13 Pain Relevance 0.65
The obtained data showed a significantly attenuated ASR and a greater magnitude of prepulse inhibition (PPI) in juvenile and adult ISIAH compared to Wistar rats.
Negative_regulation (attenuated) of ASR in juvenile associated with post-traumatic stress disorder
11) Confidence 0.38 Published 2002 Journal Physiol. Behav. Section Abstract Doc Link 11890971 Disease Relevance 1.52 Pain Relevance 0
Restraint for 2 h did not reduce stimulus responsivity in the ASR or open field activity in female rats.
Neg (not) Negative_regulation (reduce) of ASR associated with post-traumatic stress disorder
12) Confidence 0.36 Published 2005 Journal Horm Behav Section Abstract Doc Link 15811354 Disease Relevance 0.50 Pain Relevance 0.17
We also show that the radiosensitizing effect of enzastaurin is associated with suppression of tumor cell proliferation and tumor-induced angiogenesis possibly through inhibition of the Ras pathway.
Spec (possibly) Negative_regulation (inhibition) of Ras associated with cancer
13) Confidence 0.36 Published 2008 Journal Invest New Drugs Section Abstract Doc Link 17805485 Disease Relevance 1.13 Pain Relevance 0.27
The largest trial to date looking specifically at the effects of RAS blockade on insulin sensitivity was recently released.
Negative_regulation (blockade) of RAS
14) Confidence 0.36 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.94 Pain Relevance 0.10
In this review, we will examine the evidence for benefit of RAS blockade in the secondary prevention of coronary atherosclerosis.
Negative_regulation (blockade) of RAS associated with coronary artery disease
15) Confidence 0.36 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.24 Pain Relevance 0.03
This has spurred tremendous debate about the utility of RAS blockade over traditional antihypertensive therapy.
Negative_regulation (blockade) of RAS
16) Confidence 0.36 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.15 Pain Relevance 0.07
It is conceivable that RAS blockade would not only prevent the progression to overt DM but would also ameliorate the documented risk of atherosclerosis in these patients.
Negative_regulation (blockade) of RAS associated with atherosclerosis and diabetes mellitus
17) Confidence 0.36 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.75 Pain Relevance 0.04
This review article discusses the biochemical and molecular mechanisms involving the RAS in coronary atherosclerosis as well as the effects of RAS inhibition in clinical studies involving coronary atherosclerosis.



Negative_regulation (inhibition) of RAS associated with coronary artery disease
18) Confidence 0.36 Published 2007 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2350139 Disease Relevance 0.76 Pain Relevance 0
Given the potential of the differing medical therapies in these three studies, there has been some interest in further evaluating the interaction of RAS blockade and lipid lowering therapy.
Negative_regulation (blockade) of RAS
19) Confidence 0.36 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.37 Pain Relevance 0.04
Initial studies have focused on the importance of RAS blockade in left ventricular dysfunction.
Negative_regulation (blockade) of RAS associated with left ventricular dysfunction
20) Confidence 0.36 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.67 Pain Relevance 0.04

General Comments

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