INT332258

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 2.32
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf1) cytoplasm (Fgf1) cytosol (Fgf1)
extracellular space (Fgf1) extracellular region (Fgf1) proteinaceous extracellular matrix (Fgf1)
Anatomy Link Frequency
mast cells 2
Fgf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 5 99.12 Very High Very High Very High
fibrosis 16 92.28 High High
Pain 4 19.76 Low Low
Osteoarthritis 11 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 11 99.68 Very High Very High Very High
INFLAMMATION 6 99.12 Very High Very High Very High
Metaplasia 8 98.04 Very High Very High Very High
Hypoxia 31 97.20 Very High Very High Very High
Fibrosis 43 92.28 High High
Calcification 7 71.44 Quite High
Disease 7 68.80 Quite High
Heterotopic Ossification 27 67.08 Quite High
Fibrodysplasia Ossificans Progressiva 2 65.24 Quite High
Injury 6 63.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on our findings, we suggest that tissue metaplasia in arthrofibrosis results from increased inflammatory-associated oxidative stress, leading to an accumulation of mast cells (secreting FGF), driving fibroblast proliferation and creating avascular regions of hypoxia.
Positive_regulation (accumulation) of Localization (secreting) of FGF in mast cells associated with stress, inflammation, hypoxia and metaplasia
1) Confidence 0.18 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 2.32 Pain Relevance 0.23

General Comments

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