INT332262

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.94
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cma1) extracellular region (Cma1) intracellular (Cma1)
Anatomy Link Frequency
mast cell 6
cleavage 2
Cma1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 64 99.32 Very High Very High Very High
Osteoarthritis 44 98.36 Very High Very High Very High
Inflammation 20 86.08 High High
Pain 16 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 172 99.32 Very High Very High Very High
Urinary Dysfunction 4 98.96 Very High Very High Very High
Osteoarthritis 44 98.36 Very High Very High Very High
Disease 28 98.20 Very High Very High Very High
Systemic Sclerosis 20 97.48 Very High Very High Very High
INFLAMMATION 24 86.08 High High
Hypersensitivity 4 85.60 High High
Injury 24 84.80 Quite High
Parasitic Infection 4 84.56 Quite High
Hypoxia 124 82.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mast cell proliferation and activation and increased expression of chymase have also been linked to fibroproliferative diseases, such as systemic sclerosis, a fibrotic disorder of connective tissue, and neurogenic bladder fibrosis [32,33,35].
Positive_regulation (increased) of Gene_expression (expression) of chymase in Mast cell associated with fibrosis, urinary dysfunction, systemic sclerosis and disease
1) Confidence 0.41 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.40 Pain Relevance 0.05
The presence of chymase, a proteolytic enzyme, and the cleavage and activation of TGF-?
Positive_regulation (activation) of Gene_expression (presence) of chymase in cleavage
2) Confidence 0.29 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.66 Pain Relevance 0.08
In the same areas, increased numbers of chymase expressing mast cells were observed (Figure 4C, D).
Positive_regulation (increased) of Gene_expression (expressing) of chymase in mast cells
3) Confidence 0.27 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 0.90 Pain Relevance 0.21
In fibroproliferative disorders of the skin and gastrointestinal tract, mast cells undergo proliferation and activation, and show increased expression of mast cell-specific chymase [32-35].
Positive_regulation (increased) of Gene_expression (expression) of chymase in mast cell
4) Confidence 0.24 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 0.97 Pain Relevance 0.04

General Comments

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