INT332287

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.48
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (IRS1) signal transducer activity (IRS1) lipid metabolic process (LEP)
cytosol (IRS1) signal transduction (IRS1) extracellular space (LEP)
LEP (Homo sapiens)
IRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 2 77.88 Quite High
Inflammation 12 40.28 Quite Low
cytokine 16 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Syndrome 104 94.28 High High
Vascular Disease 8 84.76 Quite High
Thrombosis 14 81.96 Quite High
Necrosis 2 76.28 Quite High
Coagulation Disorder 2 61.28 Quite High
Adhesions 4 56.48 Quite High
Apoptosis 8 52.36 Quite High
Insulin Resistance 18 50.00 Quite Low
INFLAMMATION 10 40.28 Quite Low
Syndrome 2 14.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, the authors showed that leptin increases serine-138 phosphorylation of insulin receptor substrates-1 (IRS-1).
leptin Positive_regulation (increases) of Phosphorylation (phosphorylation) of IRS-1
1) Confidence 0.20 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.74 Pain Relevance 0.04
In this study, the authors showed that leptin increases serine-138 phosphorylation of insulin receptor substrates-1 (IRS-1).
leptin Positive_regulation (increases) of Phosphorylation (phosphorylation) of insulin receptor substrates-1
2) Confidence 0.14 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.74 Pain Relevance 0.04

General Comments

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