INT33229

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 6.95
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Anatomy Link Frequency
brain 2
Acb 1
neurons 1
Bad (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 26 100.00 Very High Very High Very High
antagonist 6 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
Clonidine 3 99.96 Very High Very High Very High
Nucleus accumbens 6 99.76 Very High Very High Very High
alcohol 1 99.66 Very High Very High Very High
Morphine 2 99.12 Very High Very High Very High
withdrawal 10 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 263 99.34 Very High Very High Very High
Injury 118 99.00 Very High Very High Very High
Middle Cerebral Artery Infarction 13 97.98 Very High Very High Very High
Death 102 95.84 Very High Very High Very High
Toxicity 17 95.84 Very High Very High Very High
Stroke 43 94.40 High High
Sleep Disorders 2 93.56 High High
Stress 40 92.64 High High
Coronary Heart Disease 2 91.36 High High
Drug Induced Neurotoxicity 4 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Magnolol increased the expression of phosphor ERK and Bad which resulted in inhibition of myocardial apoptosis as evidenced by TUNEL analysis and DNA laddering experiments.
Gene_expression (expression) of Bad associated with apoptosis
1) Confidence 0.70 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18641058 Disease Relevance 0.74 Pain Relevance 0.12
Apoptosis related events such as p-ERK, p-Bad, Bcl-xl and cytochrome c expression were evaluated by Western blot analysis and myocardial caspase-3 activity was also measured.
Gene_expression (expression) of Bad associated with apoptosis
2) Confidence 0.61 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18641058 Disease Relevance 0.69 Pain Relevance 0.15
-Binding Alcohol Dehydrogenase (ABAD), that is highly expressed in the brain and has been clearly shown to link A?
Gene_expression (expressed) of BAD in brain associated with alcohol
3) Confidence 0.58 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.56 Pain Relevance 0.05
The effect of the delta-opioid antagonists ICI 154,129 (1-100 micrograms, i.c.v.) and ICI 174,864 (1-100 micrograms, i.c.v.) and of the delta-agonist D-Ala2-D-Leu5-enkephalin (DADL; 1-10 micrograms, i.c.v.) on the intake of food and water of non-deprived rats was investigated.
Spec (investigated) Gene_expression (effect) of delta-agonist associated with antagonist, agonist, enkephalin and opioid
4) Confidence 0.57 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2997654 Disease Relevance 0 Pain Relevance 0.47
, Cytochrome C, mitochondrial membrane morphological changes, caspase 9, and expressions of Bad, Bid, Bcl-xL.
Gene_expression (expressions) of Bad
5) Confidence 0.27 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 0.92 Pain Relevance 0
is accompanied by reduced Bad sequestration by 14-3-3?
Gene_expression (sequestration) of Bad
6) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 1.33 Pain Relevance 0.63
These results indicate that repeated administration of a beta-agonist produces a rapid appearance of beta- and alpha 2-adrenoceptor subsensitivity, which it not followed by alpha 1-adrenoceptor changes.
Gene_expression (produces) of beta-agonist associated with agonist
7) Confidence 0.14 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3007168 Disease Relevance 0.18 Pain Relevance 0.24
Morphine (0, 0.5, 5 micrograms/0.5 microliter), the mu agonist D-Ala2, NMe-Phe4, Glyo 15-enkephalin (DAMGO; 0, 0.025, 0.25 and 2.5 micrograms/0.5 microliter), the delta agonist D-Pen2,5-enkephalin (DPEN; 0, 0.031, 0.31, 3.1 micrograms/0.5 microliter), and the kappa agonists U50488H (0, 0.0186, 0.186, 1.86 micrograms/0.5 microliter), and dynorphin (0, 0.05, 0.5, 5 micrograms/0.5 microliter) were microinfused into Acb.
Gene_expression (microinfused) of mu agonist D-Ala2 in Acb associated with nucleus accumbens, dynorphin, agonist, enkephalin and morphine
8) Confidence 0.08 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9298512 Disease Relevance 0 Pain Relevance 1.33
The inhibitory effect of clonidine (alpha2-agonist; 1 mg/kg) on the accumulation of DOPA (15-41%) and 5-HTP (22-41%) was markedly decreased or abolished after chronic WIN and precipitated withdrawal, mainly in noradrenergic and serotonergic brain regions, which indicated desensitization of alpha2-autoreceptors and alpha2-heteroreceptors regulating the synthesis of noradrenaline and 5-HT.
Gene_expression (decreased) of alpha2-agonist in brain associated with noradrenaline, agonist, withdrawal and clonidine
9) Confidence 0.03 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18709357 Disease Relevance 0 Pain Relevance 0.99
Administering melatonin prior to MCAO or at the onset of reperfusion restores the injury-induced reduction in phosphorylated AKT (p-AKT), p-Bad and Bcl-XL levels and the binding of p-Bad and 14-3-3 as well as decreases caspase-3 activation.38,39 Treatment of melatonin also suppresses the immunoreactivity of cytosolic cytochrome c oxdiase in the ischemic cortex four and 24 hours after MCAO.40 To investigate whether melatonin directly inhibits neuronal apoptosis after hypoxia/ischemia, mouse striatal neurons are cultured and subjected to oxygen and glucose deprivation (OGD).
Gene_expression (levels) of p-Bad in neurons associated with hypoxia, middle cerebral artery infarction, ischemia, injury and neurodegenerative disease
10) Confidence 0.02 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695239 Disease Relevance 1.53 Pain Relevance 0.15

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