INT332297

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.60
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTOR) Golgi apparatus (MTOR) endoplasmic reticulum (MTOR)
cytoplasm (MTOR) cytosol (MTOR) signal transduction (MTOR)
Anatomy Link Frequency
blood 2
MTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 98.00 Very High Very High Very High
Inflammation 6 93.92 High High
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tuberous Sclerosis 1 99.38 Very High Very High Very High
Metabolic Syndrome 52 98.86 Very High Very High Very High
INFLAMMATION 5 93.92 High High
Cancer 20 90.88 High High
Disease 17 88.60 High High
Vascular Disease 4 77.04 Quite High
Stress 3 70.88 Quite High
Hypoxia 3 70.60 Quite High
Apoptosis 4 57.96 Quite High
Cardiovascular Disease 5 56.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated AKT phosphorylates and inhibits tuberous sclerosis complex (TSC) and removes its inhibitory effect on mTOR.18,19
Negative_regulation (inhibitory) of mTOR Binding (effect) of associated with tuberous sclerosis
1) Confidence 0.40 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.71 Pain Relevance 0
Indeed, cytokines such as TNF alpha - which are high in MetS-patient blood cause serine phosphorylation of IRS-1 and inhibit its tyrosine phosphorylation with consequent impairment of mTOR function [16].
Negative_regulation (inhibit) of mTOR Neg (impairment) Binding (impairment) of in blood associated with metabolic syndrome and cytokine
2) Confidence 0.38 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.90 Pain Relevance 0.18

General Comments

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