INT332299

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRS1) signal transduction (IRS1) plasma membrane (IRS1)
nucleus (IRS1) cytoplasm (IRS1) signal transducer activity (IRS1)
IRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 1 72.96 Quite High
Inflammation 6 35.36 Quite Low
cytokine 8 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Syndrome 52 99.84 Very High Very High Very High
Vascular Disease 4 79.84 Quite High
Thrombosis 7 77.04 Quite High
Necrosis 1 71.36 Quite High
Coagulation Disorder 1 56.36 Quite High
Adhesions 2 51.56 Quite High
Insulin Resistance 9 50.00 Quite Low
Apoptosis 4 47.44 Quite Low
INFLAMMATION 5 35.36 Quite Low
Diabetes Mellitus 10 12.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, IS of insulin seems to be impaired at least at the IRS-1 level in MetS.
Negative_regulation (impaired) of Gene_expression (level) of IRS-1 associated with metabolic syndrome
1) Confidence 0.31 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.65 Pain Relevance 0.04

General Comments

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