INT3323

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Context Info
Confidence 0.58
First Reported 1978
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 17
Disease Relevance 7.51
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ALAS2) small molecule metabolic process (ALAS2) biosynthetic process (ALAS2)
transferase activity, transferring acyl groups (ALAS2)
Anatomy Link Frequency
tubes 2
ALAS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 99.54 Very High Very High Very High
potassium channel 1 90.40 High High
anesthesia 1 78.64 Quite High
Clonidine 1 48.52 Quite Low
Pain 37 37.32 Quite Low
Glutamate 8 9.16 Low Low
Disease Link Frequency Relevance Heat
Sideroblastic Anemia 120 100.00 Very High Very High Very High
Porphyria 42 100.00 Very High Very High Very High
Disease 216 99.10 Very High Very High Very High
Starvation 42 97.36 Very High Very High Very High
Anaemia 144 96.92 Very High Very High Very High
Death 91 96.80 Very High Very High Very High
Hepatic Porphyrias 2 96.68 Very High Very High Very High
Repression 16 95.68 Very High Very High Very High
Stress 39 95.40 Very High Very High Very High
Iron Overload 192 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IRP1 converts to its IRE-binding form and inhibits the expression of ALAS2 in heme synthesis.
Gene_expression (expression) of ALAS2
1) Confidence 0.58 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.18 Pain Relevance 0
The GLRX5 knockdown activates IRPs and thereby decreases the level of ALAS2 expression and interrupts heme biosynthesis, but activated IRPs cannot repress FPN1b expression, which is induced during the stress response to mitochondrial iron overload and worsens cytosolic iron deficiency in eythroid cells (Figure 3).
Gene_expression (expression) of ALAS2 associated with stress, anaemia, porphyria and iron overload
2) Confidence 0.58 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 1.04 Pain Relevance 0
This simple method should facilitate screening for those drugs which induce the synthesis of delta-aminolevulinate synthase and/or cytochrome P-450 and are potentially dangerous to patients with hereditary hepatic porphyria.
Gene_expression (synthesis) of delta-aminolevulinate synthase associated with hepatic porphyrias
3) Confidence 0.57 Published 1978 Journal Biochim. Biophys. Acta Section Abstract Doc Link 708789 Disease Relevance 0.32 Pain Relevance 0
S cluster, IRP1 of zebrafish is activated to an IRE-binding protein, which blocks the expression of ALAS2, the first enzyme of heme biosynthesis in erythroid cells, because the ALAS2 transcript contains an iron responsive element (IRE) in its 5?
Gene_expression (expression) of ALAS2 associated with porphyria
4) Confidence 0.52 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.75 Pain Relevance 0
However, the situation is totally different in erythroid cells, which express a heme synthetic ALAS2 isoform that contains a 5?
Gene_expression (express) of ALAS2
5) Confidence 0.51 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.76 Pain Relevance 0
sulfur cluster biogenesis; it also occurs in other diseases, such as the sideroblastic anemia caused by ALAS2 mutations, even though ALAS2 mediates the first condensation of heme biosynthesis and is not directly involved in Fe?
Gene_expression (mutations) of ALAS2 associated with porphyria, sideroblastic anemia and disease
6) Confidence 0.51 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.66 Pain Relevance 0
On the basis of the fact that mutations of SLC25A38, SLC19A2, ABCB7, and heme synthetic ALAS2 all cause a similar sideroblastic anemia phenotype (80) and the prediction that SLC25A38 may provide the glycine substrate of heme biosynthesis and SLC19A2 may provide thiamine for pyruvate dehydrogenase, it is possible that ABCB7 exports a heme or heme precursor molecule to the cytosol that conveys a signal about mitochondrial iron status to the cytosolic/nuclear compartment.
Gene_expression (synthetic) of ALAS2 associated with porphyria and sideroblastic anemia
7) Confidence 0.51 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.47 Pain Relevance 0
However, the situation is totally different in erythroid cells, which express a heme synthetic ALAS2 isoform that contains a 5?
Gene_expression (synthetic) of ALAS2
8) Confidence 0.51 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.75 Pain Relevance 0
On the basis of the fact that mutations of SLC25A38, SLC19A2, ABCB7, and heme synthetic ALAS2 all cause a similar sideroblastic anemia phenotype (80) and the prediction that SLC25A38 may provide the glycine substrate of heme biosynthesis and SLC19A2 may provide thiamine for pyruvate dehydrogenase, it is possible that ABCB7 exports a heme or heme precursor molecule to the cytosol that conveys a signal about mitochondrial iron status to the cytosolic/nuclear compartment.
Gene_expression (biosynthesis) of ALAS2 associated with porphyria and sideroblastic anemia
9) Confidence 0.51 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.50 Pain Relevance 0
Choosing PEG tubes as the method to deliver ANH was partly attributed to reimbursement issues.
Gene_expression (deliver) of ANH in tubes
10) Confidence 0.05 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC1997114 Disease Relevance 0 Pain Relevance 0
Most informants stated that they believe that the provision of ANH is inherently necessary for anyone who cannot take food and fluids orally.
Gene_expression (provision) of ANH
11) Confidence 0.05 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC1997114 Disease Relevance 0.66 Pain Relevance 0
Informants who routinely provided ANH tended to report that they did not discuss possible prognoses or alternative feeding methods as mentioned above.
Gene_expression (provided) of ANH
12) Confidence 0.05 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC1997114 Disease Relevance 0 Pain Relevance 0
Finally, the current reimbursement system provides incentives favoring PEG tube instead of other ANH methods.
Gene_expression (methods) of ANH in tube
13) Confidence 0.05 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC1997114 Disease Relevance 0.23 Pain Relevance 0
Nonetheless, Japanese physicians usually claim that they have no choice but to provide ANH to such patients [20].
Neg (no) Gene_expression (provide) of ANH
14) Confidence 0.05 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC1997114 Disease Relevance 0.32 Pain Relevance 0
We don't actually take the family's opinion into account, either. "

Physicians who offer the option of withholding or providing ANH

Gene_expression (providing) of ANH
15) Confidence 0.05 Published 2007 Journal BMC Geriatr Section Body Doc Link PMC1997114 Disease Relevance 0.06 Pain Relevance 0
It seems apparent that end-of-life education should be provided to medical providers in Japan to change the automatic assumption that ANH must be provided.



Gene_expression (provided) of ANH
16) Confidence 0.04 Published 2007 Journal BMC Geriatr Section Abstract Doc Link PMC1997114 Disease Relevance 0.21 Pain Relevance 0
Autoantibodies against the glutamate receptor subunits epsilon2 and delta2 were detected in both the CSF and serum, but these antibodies in the CSF became normal during the clinical course.
Gene_expression (detected) of delta2 associated with glutamate receptor
17) Confidence 0.02 Published 2007 Journal Brain Nerve Section Abstract Doc Link 17533979 Disease Relevance 0.61 Pain Relevance 0.21

General Comments

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