INT332310

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.26
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx3) Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 2
P2rx3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 54 84.48 Quite High
depression 21 82.00 Quite High
Neurotransmitter 9 81.72 Quite High
Migraine 54 50.00 Quite Low
agonist 30 5.00 Very Low Very Low Very Low
headache 21 5.00 Very Low Very Low Very Low
Trigeminal ganglion neurons 15 5.00 Very Low Very Low Very Low
qutenza 15 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
Potency 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 9 89.36 High High
Pain 57 84.48 Quite High
Depression 21 82.00 Quite High
Ganglion Cysts 33 50.00 Quite Low
Migraine With Aura 15 50.00 Quite Low
Migraine Disorders 39 5.00 Very Low Very Low Very Low
Epilepsy 9 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Headache 9 5.00 Very Low Very Low Very Low
Neurological Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, calcineurin inhibition enhanced P2X3 receptor threonine phosphorylation, a process that was previously associated with PKC-dependent potentiation of P2X3 receptor function especially after stimulation with NGF [9].
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of P2X3
1) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.26 Pain Relevance 0.20
-agatoxin (200 nM, 24 h), P2X3 serine phosphorylation was significantly (p = 0.027) increased in KI neurons (n = 3; Fig. 5A).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of P2X3 in neurons
2) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
This treatment reversed the KI phenotype by decreasing the P2X3 receptor current (44 ± 5%, n = 20, p = 0.03; Fig. 6C) and in KI increased P2X3 receptor serine phosphorylation (134 ± 16%, n = 4, p = 0.03; Fig. 6D).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of P2X3
3) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0.03

General Comments

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