INT332310

Context Info Confidence 0.46 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.26 Pain Relevance 0.24

transport (P2rx3) Golgi apparatus (P2rx3)

Anatomy Link Frequency neurons 2 P2rx3 (Mus musculus)

Pain Link Frequency Relevance Heat Pain 54 84.48 depression 21 82.00 Neurotransmitter 9 81.72 Migraine 54 50.00 agonist 30 5.00 headache 21 5.00 Trigeminal ganglion neurons 15 5.00 qutenza 15 5.00 imagery 12 5.00 Potency 9 5.00

Disease Link Frequency Relevance Heat Nociception 9 89.36 Pain 57 84.48 Depression 21 82.00 Ganglion Cysts 33 50.00 Migraine With Aura 15 50.00 Migraine Disorders 39 5.00 Epilepsy 9 5.00 Targeted Disruption 9 5.00 Headache 9 5.00 Neurological Disease 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, calcineurin inhibition enhanced P2X3 receptor threonine phosphorylation, a process that was previously associated with PKC-dependent potentiation of P2X3 receptor function especially after stimulation with NGF [9].

Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of P2X3

1) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.26 Pain Relevance 0.20

-agatoxin (200 nM, 24 h), P2X3 serine phosphorylation was significantly (p = 0.027) increased in KI neurons (n = 3; Fig. 5A).

Positive_regulation (increased) of Phosphorylation (phosphorylation) of P2X3 in neurons

2) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0

This treatment reversed the KI phenotype by decreasing the P2X3 receptor current (44 ± 5%, n = 20, p = 0.03; Fig. 6C) and in KI increased P2X3 receptor serine phosphorylation (134 ± 16%, n = 4, p = 0.03; Fig. 6D).

Positive_regulation (increased) of Phosphorylation (phosphorylation) of P2X3

3) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0.03

General Comments

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