INT332311

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.16
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Rbm39) RNA binding (Rbm39) nucleus (Rbm39)
Anatomy Link Frequency
neurons 4
ganglia 2
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 8 100.00 Very High Very High Very High
Trigeminal ganglion neurons 20 98.70 Very High Very High Very High
Pain 73 88.76 High High
Morphine 120 88.72 High High
Migraine 72 75.00 Quite High
imagery 16 74.36 Quite High
Spinal cord 9 72.48 Quite High
Dopamine 14 66.56 Quite High
Nucleus accumbens 3 57.40 Quite High
opiate 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 44 98.54 Very High Very High Very High
Nociception 52 97.60 Very High Very High Very High
Pain 77 88.76 High High
Stress 3 76.16 Quite High
Migraine With Aura 20 75.00 Quite High
Migraine Disorders 52 66.84 Quite High
Neuroblastoma 1 27.96 Quite Low
Depression 29 5.00 Very Low Very Low Very Low
Targeted Disruption 13 5.00 Very Low Very Low Very Low
Epilepsy 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased affinity of opioid receptors has been previously shown to result from a decrease of phosphorylation, oligomerization and allosterism of opioid receptors [45].
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of receptors associated with opioid receptor
1) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.08 Pain Relevance 0.64
Although no significant difference in membrane expression of knockin receptors was found, serine phosphorylation of knockin P2X3 receptors was constitutively decreased and restored by KN-93.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of receptors
2) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2940876 Disease Relevance 0.54 Pain Relevance 0.39
The present results suggest that the CACNA1A mutation conferred a novel molecular phenotype to P2X3 receptors of trigeminal ganglion neurons via CaMKII-dependent activation of calcineurin that selectively impaired the serine phosphorylation state of such receptors, thus potentiating their effects in transducing trigeminal nociception.



Negative_regulation (impaired) of Phosphorylation (phosphorylation) of receptors in neurons associated with nociception, ganglion cysts and trigeminal ganglion neurons
3) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2940876 Disease Relevance 0.40 Pain Relevance 0.15
However, we did observe decreased serine phosphorylation of P2X3 receptors as the molecular phenotype of CaV2.1-immunoreactive neurons in KI ganglia and in culture.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of receptors in ganglia
4) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.14 Pain Relevance 0.11
R192Q KI neurons lack constitutive serine phosphorylation of P2X3 receptors
Negative_regulation (lack) of Phosphorylation (phosphorylation) of receptors in neurons
5) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0

General Comments

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