INT332327

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.40
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Myoz1) plasma membrane (Camk2a) kinase activity (Camk2a)
cytoplasm (Camk2a)
Anatomy Link Frequency
neurons 1
Camk2a (Mus musculus)
Myoz1 (Mus musculus)
Pain Link Frequency Relevance Heat
Trigeminal ganglion neurons 5 99.90 Very High Very High Very High
Migraine 18 75.00 Quite High
imagery 4 54.56 Quite High
Pain 18 47.24 Quite Low
agonist 10 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
headache 7 5.00 Very Low Very Low Very Low
qutenza 5 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 11 99.74 Very High Very High Very High
Nociception 3 94.52 High High
Migraine With Aura 5 75.00 Quite High
Pain 19 47.24 Quite Low
Migraine Disorders 13 47.04 Quite Low
Depression 7 5.00 Very Low Very Low Very Low
Epilepsy 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Headache 3 5.00 Very Low Very Low Very Low
Neurological Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results suggest that the CACNA1A mutation conferred a novel molecular phenotype to P2X3 receptors of trigeminal ganglion neurons via CaMKII-dependent activation of calcineurin that selectively impaired the serine phosphorylation state of such receptors, thus potentiating their effects in transducing trigeminal nociception.



CaMKII Positive_regulation (activation) of calcineurin in neurons associated with nociception, ganglion cysts and trigeminal ganglion neurons
1) Confidence 0.05 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2940876 Disease Relevance 0.40 Pain Relevance 0.15

General Comments

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