INT332346

Context Info Confidence 0.62 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cytoplasm (Plk1) mitosis (Plk1) chromosome (Plk1) nucleus (Plk1) cytoskeleton (Plk1) cell cycle (Plk1)

Plk1 (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 3 5.00 isoflurane 3 5.00 cytokine 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 12 45.60 Necrosis 2 5.00 Cancer 2 5.00 Sprains And Strains 1 5.00 Hyperplasia 1 5.00 Apoptosis 1 5.00 Death 1 5.00 Congenital Anomalies 1 5.00 Injury 1 5.00 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Among these, Cdk1 is the main kinase player during G2/M transition [39] which controls execution of a transcriptional program required for mitosis through phosphorylation of Plk1 and Aurora B and subsequent activation of FoxM1, a key transcription factor during G2/M transition [35], [40].

Phosphorylation (phosphorylation) of Plk1

1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0

General Comments

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