INT33237

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Context Info
Confidence 0.39
First Reported 1985
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 1.30
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fst) nucleus (Fst) cellular_component (Fst)
cytoplasm (Fst)
Anatomy Link Frequency
neuronal 1
muscle 1
fornix 1
Fst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 64 100.00 Very High Very High Very High
depression 43 100.00 Very High Very High Very High
Eae 27 100.00 Very High Very High Very High
5HT 2 99.18 Very High Very High Very High
noradrenaline 15 98.88 Very High Very High Very High
Serotonin 41 97.28 Very High Very High Very High
Dopamine 215 94.44 High High
Hippocampus 9 84.72 Quite High
Clonidine 1 83.44 Quite High
Catecholamine 6 75.12 Quite High
Disease Link Frequency Relevance Heat
Depression 58 100.00 Very High Very High Very High
Stress 41 100.00 Very High Very High Very High
Overactive Bladder 9 98.16 Very High Very High Very High
Sprains And Strains 12 80.80 Quite High
Disease 24 56.88 Quite High
Carcinoma 2 18.72 Low Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low
Shock 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 5 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was undertaken to investigate the effects of the forced swimming test (FST) on the contractile response of isolated rat detrusor muscle and to examine the effects of in vivo treatments of fluoxetine and sertraline on altered detrusor muscle contractility.
Spec (investigate) Regulation (effects) of FST in muscle associated with overactive bladder and fluoxetine
1) Confidence 0.39 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19211979 Disease Relevance 0.59 Pain Relevance 0.30
In conclusion, the present work supports the preliminary hypothesis about a direct serotonin and neuronal plasticity relationship [26] as it proposes that changes in central 5-HT levels obtained either within a behavioural test resulting in stress and/or depression states (FST) or via selective pharmacological treatments (i.e.
Regulation (resulting) of FST in neuronal associated with stress, depression and serotonin
2) Confidence 0.35 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0.35 Pain Relevance 0.50
Therefore, this data indicate that the reduction of 5HT levels and Tyr-tub expression following FST is not altered significantly by the manipulation of the animal when submitted to i.p. treatment, thus supporting both these reductions as directly related to the FST and independent from the putative stressful manipulation of the animal due to the systemic injection.
Neg (not) Regulation (altered) of FST associated with 5ht
3) Confidence 0.35 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0 Pain Relevance 0.12
Up-regulated genes include Ldhc, Stab2, Nmu, Fst, Nts, and Tac2 whereas down-regulated transcripts included Tac1 (Table 2).
Regulation (regulated) of Fst
4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.18
No effects in the FST were observed 15 min after noradrenaline injection or after intracaudate noradrenaline administration.
Neg (No) Regulation (effects) of FST associated with eae and noradrenaline
5) Confidence 0.24 Published 1985 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2997825 Disease Relevance 0 Pain Relevance 0.94
Injection of CoCl2 into structures surrounding the BNST, such as anterior commissure, internal capsule or fornix, before the pretest (173 ± 11 vs 182 ± 23 s, t5 = 0.385, P > 0.05) or the test (189 ± 19 vs 162 ± 12 s, t6 = 1.244, P > 0.05) did not affect immobility time in the FST.


Neg (not) Regulation (affect) of FST in fornix
6) Confidence 0.23 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2887770 Disease Relevance 0 Pain Relevance 0.08
RESULTS: VLX, FLX, or DMI by themselves at these doses did not induce changes in the FST at short intervals after their injection (from 1 to 7 days).
Neg (not) Regulation (changes) of FST
7) Confidence 0.23 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18795270 Disease Relevance 0 Pain Relevance 0
Parameter values (Ne, number of populations, and start FST) were altered one at a time in order to assess the impact of the parameter on experimental power.


Regulation (altered) of FST
8) Confidence 0.22 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2942893 Disease Relevance 0.30 Pain Relevance 0
Two different methods for detecting selection were considered: 1) detection of loci with lower-than-expected values of FST between selectively bred aquaculture populations (hereafter referred to as farmed populations), and 2) detection of loci with higher-than-expected values of FST between a pool of farmed populations and a pool of wild populations.
Regulation (values) of FST
9) Confidence 0.22 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2942893 Disease Relevance 0 Pain Relevance 0
FST values were computed for each pair of Icelandic regions, yielding an average of 0.0026 (Table 2).
Regulation (values) of FST
10) Confidence 0.20 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2684636 Disease Relevance 0 Pain Relevance 0
The effect of fluoxetine on immobility time on the FST can be stated thus: for every 100 mg/L increase in fluoxetine, immobility time decreases by 25 seconds (CI95% = 4 to 46 seconds; p = 0.021).
Regulation (effect) of FST associated with eae and fluoxetine
11) Confidence 0.13 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2496911 Disease Relevance 0 Pain Relevance 0.36
These include follistatin, neuromedin U, and tachykinin 2 which were up-regulated.
Regulation (regulated) of follistatin
12) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001483 Disease Relevance 0.06 Pain Relevance 0.51

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