INT33241

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Context Info
Confidence 0.10
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.24
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Hepatocyte 1
osteoblasts 1
spinal cords 1
annulus 1
INSRR (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 9 100.00 Very High Very High Very High
Cholecystokinin 3 100.00 Very High Very High Very High
agonist 3 100.00 Very High Very High Very High
Immobilon 1 100.00 Very High Very High Very High
Enkephalin 11 98.80 Very High Very High Very High
dexamethasone 5 97.96 Very High Very High Very High
narcan 1 97.20 Very High Very High Very High
antagonist 1 96.84 Very High Very High Very High
Opioid 2 96.40 Very High Very High Very High
bradykinin 5 89.00 High High
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 4 94.56 High High
Osteoporosis 36 94.28 High High
Hypersensitivity 2 81.40 Quite High
Inflammatory Pain 2 80.72 Quite High
Pain 11 78.80 Quite High
Nociception 5 77.76 Quite High
Disease 5 72.96 Quite High
INFLAMMATION 13 66.72 Quite High
Hypercalcemia 1 65.28 Quite High
Peripheral Arterial Disease 1 58.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding sites for the receptor ligands 3H-quinuclidinylbenzilate, 3H-alpha-bungarotoxin (3H-alpha-Btx), 3H-etorphine and 3H-strychnine were localized autoradiographically at cervical, thoracic and lumbar levels of spinal cords from post-mortem human control subjects and subjects with amyotrophic lateral sclerosis (ALS).
Localization (localized) of receptor in spinal cords associated with motor neuron diseases and immobilon
1) Confidence 0.10 Published 1985 Journal Acta Neurol. Scand. Section Abstract Doc Link 2998142 Disease Relevance 0.32 Pain Relevance 0.27
The authors demonstrate the successful and rapid retargeting of a G-protein-coupled receptor (cholecystokinin receptor A, CCKAR), an ion channel (the transient receptor potential cation channel, subfamily M, member 8, TRPM8), and a GFP-c-Jun(1-79) fusion protein into the specific loci in these cell lines and show that these retargeted cell lines exhibit functional and pharmacological responses consistent with those reported in the literature.
Localization (retargeting) of receptor associated with member 8 and cholecystokinin
2) Confidence 0.05 Published 2009 Journal J Biomol Screen Section Abstract Doc Link 19820070 Disease Relevance 0 Pain Relevance 0.34
The authors demonstrate the successful and rapid retargeting of a G-protein-coupled receptor (cholecystokinin receptor A, CCKAR), an ion channel (the transient receptor potential cation channel, subfamily M, member 8, TRPM8), and a GFP-c-Jun(1-79) fusion protein into the specific loci in these cell lines and show that these retargeted cell lines exhibit functional and pharmacological responses consistent with those reported in the literature.
Localization (retargeting) of receptor associated with member 8 and cholecystokinin
3) Confidence 0.04 Published 2009 Journal J Biomol Screen Section Abstract Doc Link 19820070 Disease Relevance 0 Pain Relevance 0.34
The authors demonstrate the successful and rapid retargeting of a G-protein-coupled receptor (cholecystokinin receptor A, CCKAR), an ion channel (the transient receptor potential cation channel, subfamily M, member 8, TRPM8), and a GFP-c-Jun(1-79) fusion protein into the specific loci in these cell lines and show that these retargeted cell lines exhibit functional and pharmacological responses consistent with those reported in the literature.
Localization (retargeting) of receptor associated with member 8 and cholecystokinin
4) Confidence 0.04 Published 2009 Journal J Biomol Screen Section Abstract Doc Link 19820070 Disease Relevance 0 Pain Relevance 0.35
DADLE (delta receptor agonist) increased O2- release in 10(-11) M concentration, while DAGO (mu receptor agonist) had no effect in any concentration examined.
Localization (release) of receptor associated with agonist
5) Confidence 0.02 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837964 Disease Relevance 0 Pain Relevance 1.26
Confocal laser scanning microscopy and immunogold labelling experiment revealed that the recombinant receptor was predominantly localized in the intracellular membranes.
Localization (localized) of recombinant receptor
6) Confidence 0.02 Published 2007 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 17445746 Disease Relevance 0 Pain Relevance 0
Confocal laser scanning microscopy and immunogold staining revealed that the recombinant receptor was predominantly localized intracellularly.
Localization (localized) of recombinant receptor
7) Confidence 0.01 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16740128 Disease Relevance 0.13 Pain Relevance 0.28
OPG is a soluble decoy RANK receptor, secreted by osteoblasts, that binds surface RANK ligand (RANKL) on osteoblasts.
Localization (secreted) of RANK receptor in osteoblasts
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958849 Disease Relevance 0.34 Pain Relevance 0.08
We studied immunohistochemical localization of BDNF and its receptor in the human annulus, quantified the percentage of outer annulus and inner annulus cells and nucleus cells positive for BDNF immunolocalization, and studied the gene expression of BDNF and its receptor using microarray analysis.


Localization (localization) of receptor in annulus
9) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575628 Disease Relevance 0.32 Pain Relevance 0.16
Hepatocyte growth factor is secreted by vascular endothelial cells and smooth muscle cells, and the hepatocyte growth factor receptor, c-met, was also observed in these vascular cells.
Localization (secreted) of receptor in Hepatocyte
10) Confidence 0.01 Published 2005 Journal Expert Rev Cardiovasc Ther Section Abstract Doc Link 15889978 Disease Relevance 0.13 Pain Relevance 0

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