INT33243

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Context Info
Confidence 0.12
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 9.70
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HP)
Anatomy Link Frequency
urine 2
blood 1
endothelial cell 1
stage 1 1
spinal cords 1
HP (Homo sapiens)
Pain Link Frequency Relevance Heat
Immobilon 1 100.00 Very High Very High Very High
Angina 13 96.12 Very High Very High Very High
Bile 2 93.32 High High
Osteoarthritis 36 91.68 High High
Inflammation 9 91.44 High High
COX2 7 90.76 High High
spinal inflammation 86 90.24 High High
cINOD 18 89.64 High High
beta blocker 7 87.92 High High
Codeine 1 86.16 High High
Disease Link Frequency Relevance Heat
Hypertension 544 100.00 Very High Very High Very High
Congenital Syphilis 22 99.70 Very High Very High Very High
Disease 123 99.16 Very High Very High Very High
Disorder Of Lipid Metabolism 3 98.00 Very High Very High Very High
Cancer 355 97.76 Very High Very High Very High
Prehypertension 17 97.60 Very High Very High Very High
Cv General 3 Under Development 27 96.12 Very High Very High Very High
Syndrome 7 94.96 High High
Motor Neuron Diseases 4 94.56 High High
Trepenoma Infection 172 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As there was no effect of treatment order on BP decrease of either intervention, subjects were classified as having prehypertension or stage 1 hypertension based on placebo values for further analysis of the treatment effects.
Localization (decrease) of BP in stage 1 associated with prehypertension and hypertension
1) Confidence 0.12 Published 2010 Journal Nutr J Section Body Doc Link PMC2989300 Disease Relevance 1.32 Pain Relevance 0
Binding sites for the receptor ligands 3H-quinuclidinylbenzilate, 3H-alpha-bungarotoxin (3H-alpha-Btx), 3H-etorphine and 3H-strychnine were localized autoradiographically at cervical, thoracic and lumbar levels of spinal cords from post-mortem human control subjects and subjects with amyotrophic lateral sclerosis (ALS).
Localization (localized) of Binding in spinal cords associated with motor neuron diseases and immobilon
2) Confidence 0.09 Published 1985 Journal Acta Neurol. Scand. Section Abstract Doc Link 2998142 Disease Relevance 0.32 Pain Relevance 0.27
Some evidence suggests that two effects of VSP inhibition on the systemic vasculature contribute to BP elevation: 1) increased vascular tone because of decreased nitric oxide production and 2) increased peripheral resistance because of endothelial cell damage and dysfunction (24–27).
Localization (elevation) of BP in endothelial cell
3) Confidence 0.08 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.78 Pain Relevance 0.03
Patients should be instructed to take their BP medication even if fasting to ensure accurate representation of the treated BP on office visits.
Localization (representation) of BP
4) Confidence 0.08 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.45 Pain Relevance 0.16
Temporary cessation of kinase inhibitors can be useful when hypertension is difficult to control, when patients report symptoms of excess BP elevation (13), or when the BP elevation is one of a constellation of multiple drug-associated toxic effects.
Localization (elevation) of BP associated with hypertension
5) Confidence 0.08 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.46 Pain Relevance 0
Excessively aggressive BP lowering or inappropriate selection of antihypertensive agents could have consequences for cancer patients that are as damaging as the cardiovascular complications of VSP inhibitors, and so physician competence and judgment are essential for successful implementation of these recommendations.
Localization (selection) of BP associated with cancer
6) Confidence 0.08 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.32 Pain Relevance 0.08
If any of these agents is indicated during the course of VSP inhibitor therapy, anticipate further BP elevation and either increase the antihypertensive therapy or the frequency of BP measurements accordingly.
Localization (elevation) of BP
7) Confidence 0.08 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.40 Pain Relevance 0.18
Finally, although bevacizumab is currently the most commonly prescribed VSP inhibitor, there are no published prospectively collected data on the time course of BP elevation.
Localization (elevation) of BP
8) Confidence 0.08 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.20 Pain Relevance 0
Temporary cessation of kinase inhibitors can be useful when hypertension is difficult to control, when patients report symptoms of excess BP elevation (13), or when the BP elevation is one of a constellation of multiple drug-associated toxic effects.
Localization (elevation) of BP associated with hypertension
9) Confidence 0.08 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.46 Pain Relevance 0
Interestingly, binding of SULT1C1, 1B1, and 1E1 to resveratrol was only observed in the absence of PAP, but all are active toward this substrate.
Localization (observed) of binding
10) Confidence 0.06 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0.03
However, the exact localization of the allosteric binding site and the potentiation mechanism at the molecular level are presently unknown.
Localization (localization) of binding
11) Confidence 0.05 Published 2006 Journal J Mol Model Section Abstract Doc Link 16372175 Disease Relevance 0.10 Pain Relevance 0.12
When, however, considering the oldest osseous evidence of congenital syphilis as being that reported for Costebelle in France circa 1,600 yBP [65] and for Metaponto in Italy about 2,400 yBP [57], these values correspond to 9.25×10?
Localization (circa) of yBP associated with congenital syphilis
12) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2793018 Disease Relevance 0.61 Pain Relevance 0
When, however, considering the oldest osseous evidence of congenital syphilis as being that reported for Costebelle in France circa 1,600 yBP [65] and for Metaponto in Italy about 2,400 yBP [57], these values correspond to 9.25×10?
Localization (reported) of yBP associated with congenital syphilis
13) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2793018 Disease Relevance 0.61 Pain Relevance 0
In the case of intravenous administration, 80% of the administered BP is excreted into the urine within 24 h, while only 5% is excreted into the feces.
Localization (excreted) of BP in urine
14) Confidence 0.02 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.38 Pain Relevance 0.05
Because BP is excreted into the urine within 24 h, it is interesting to note that five continuous doses showed significant tumor inhibition.
Localization (excreted) of BP in urine associated with cancer
15) Confidence 0.02 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.77 Pain Relevance 0.04
In conclusion, fibrinogen beta chain, fibrinogen gamma chain, alpha1-antitrypsin, transthyretinc, haptoglobin beta chain, ApoA-IV, ApoA-I and haptoglobin alpha2 chain are differentially expressed in the patients with unstable angina blood-stasis syndrome and control group, some differentially expressed proteins were correlated with inflammatory reaction or lipid metabolic disorder, and these proteins could provide clues to the study and discovery of new protein targets for antianginal drugs.
Localization (alpha1-antitrypsin) of haptoglobin beta chain in blood associated with metabolic disorder, angina, inflammation and syndrome
16) Confidence 0.00 Published 2009 Journal Guang Pu Xue Yu Guang Pu Fen Xi Section Abstract Doc Link 19810551 Disease Relevance 1.38 Pain Relevance 0.59
These proteins were identified as Ig gamma-1 chain C region, dynein heavy chain, fibrinogen gamma chain precursor, catalase, SH3 and multiple ankyrin repeat domains protein 2, haptoglobin precursor, DNA-dependent protein kinase catalytic subunit, apolipoprotein A-I precursor, serotransferrin precursor, microtubule-actin crosslinking factor 1 isoform 4, and intersectin 1.
Localization (multiple) of haptoglobin precursor in SH3 associated with disorder of lipid metabolism
17) Confidence 0.00 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.13 Pain Relevance 0.65

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