INT332481

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (SGPP2) endoplasmic reticulum (SGPP2) protein binding, bridging (ANXA1)
cilium (ANXA1) protein complex (ANXA1) lipid metabolic process (ANXA1)
Anatomy Link Frequency
leukocyte 1
ANXA1 (Homo sapiens)
SGPP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 56 95.44 Very High Very High Very High
Osteoarthritis 2 58.00 Quite High
agonist 4 50.00 Quite Low
rheumatoid arthritis 6 48.84 Quite Low
cINOD 10 46.32 Quite Low
cytokine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
acular 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 64 95.44 Very High Very High Very High
Cancer 6 74.44 Quite High
Apoptosis 10 66.88 Quite High
Osteoarthritis 2 58.00 Quite High
Adhesions 4 52.64 Quite High
Brain Injury 2 50.68 Quite High
Colitis 2 49.40 Quite Low
Rheumatoid Arthritis 6 48.84 Quite Low
Inflammatory Bowel Disease 2 26.12 Quite Low
Arthritis 4 20.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A succinct list of the interesting genes affected by both AnxA1 and Ac2-26 would include SGPP2 (sphingosine-1-phosphate phosphatase), an enzyme involved in the degradation of sphingosine-1-phosphate (S1P), a lipid mediator involved in several physiological processes including cell growth and survival, and leukocyte migration [19], [20].
AnxA1 Regulation (affected) of SGPP2 in leukocyte
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.32 Pain Relevance 0.10
In conclusion, this study reports the novel observation that AnxA1 is a regulator of SGPP2 in an ALX-dependent fashion.
AnxA1 Regulation (regulator) of SGPP2
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.69 Pain Relevance 0.13

General Comments

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