INT332483

Context Info Confidence 0.21 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.23 Pain Relevance 0.04

small molecule metabolic process (SGPP2) extracellular region (JAG1) endoplasmic reticulum (SGPP2) structural molecule activity (JAG1) plasma membrane (JAG1)

Anatomy Link Frequency immune system 1 JAG1 (Homo sapiens) SGPP2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 28 83.60 agonist 2 50.00 chemokine 2 23.16 cytokine 2 16.44 cINOD 5 5.00 rheumatoid arthritis 3 5.00 aspirin 1 5.00 Inflammatory response 1 5.00 acular 1 5.00 addiction 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 32 83.60 Multiple Sclerosis 1 80.08 Cytomegalovirus Infection 7 68.08 Cancer 3 26.24 Apoptosis 5 5.00 Rheumatoid Arthritis 3 5.00 Arthritis 2 5.00 Bacterial Respiratory Disease 2 5.00 Adhesions 2 5.00 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We focused here on three genes: SGPP2, as it controls the trafficking of lymphocytes in the thymus and lymphoid organs [19], JAG1, which is related to T cell function and could be related to the role of AnxA1 in the adaptive immune system [13], [29], and JAM3, as previously mentioned.

JAG1 Binding (trafficking) of SGPP2 in immune system

1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

This test has worked.