INT332516

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.24
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (JAM3) extracellular region (JAM3) cell adhesion (JAM3)
plasma membrane (JAM3)
Anatomy Link Frequency
capillary 1
JAM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 56 99.78 Very High Very High Very High
Arthritis 2 97.36 Very High Very High Very High
rheumatoid arthritis 6 80.40 Quite High
Osteoarthritis 2 67.24 Quite High
agonist 4 50.00 Quite Low
substance P 1 33.20 Quite Low
bradykinin 1 32.52 Quite Low
Inflammatory mediators 3 31.32 Quite Low
cINOD 10 7.36 Low Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 65 99.78 Very High Very High Very High
Adhesions 15 99.30 Very High Very High Very High
Arthritis 4 97.36 Very High Very High Very High
Disease 10 86.08 High High
Rheumatoid Arthritis 6 80.40 Quite High
Osteoarthritis 2 67.24 Quite High
Cancer 88 59.68 Quite High
Metastasis 76 50.00 Quite Low
Breast Cancer 42 50.00 Quite Low
Brain Injury 4 41.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, AnxA1null mice display a higher degree of leukocyte trans-migration across post-capillary venules in response to a variety of stimuli [45], which could be consequent to higher JAM3 expression hence function to sustain cell migration.
Gene_expression (expression) of JAM3 in capillary
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.14 Pain Relevance 0.07
Our new data indicate that, in inflammatory settings, expression of JAM-3 may be modulated upon AnxA1 administration (pharmacological studies) or AnxA1 deficiency (patho-physiological investigations).
Gene_expression (expression) of JAM-3 associated with inflammation
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.94 Pain Relevance 0.33
The proteins of the TJs include the junctional adhesion molecules (JAM) (JAM-1, JAM-2 and JAM-3), occludin, the claudins, and zonula occludin proteins (ZO-1 and ZO-2).
Gene_expression (proteins) of JAM-3 associated with adhesions
3) Confidence 0.11 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3021881 Disease Relevance 0.16 Pain Relevance 0

General Comments

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