INT332526

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.41
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HSH2D) cytoplasm (HSH2D)
HSH2D (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 6 93.52 High High
Inflammation 84 83.12 Quite High
Inflammatory mediators 3 15.20 Low Low
Inflammatory response 3 9.84 Low Low
addiction 3 8.44 Low Low
cINOD 15 5.00 Very Low Very Low Very Low
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 96 83.12 Quite High
Alzheimer's Dementia 3 80.40 Quite High
Cytomegalovirus Infection 21 70.80 Quite High
Apoptosis 15 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 9 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 6 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection of ALX receptor in HEK293 Cells
Positive_regulation (Transfection) of Gene_expression (Transfection) of ALX receptor
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0 Pain Relevance 0
HEK293 cells transfected with ALX receptor were treated with 0.5 µM AnxA1 or with 10 µM Ac2-26 for 4 hours; these concentrations were validated to produce rapid signalling responses (e.g. phospho-ERK) via ALX activation [16].
Positive_regulation (transfected) of Gene_expression (transfected) of ALX receptor
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.12 Pain Relevance 0.05
We have recently transfected human FPR and ALX (the only two receptors of the group expressed by human PMN) in HEK293 cells finding that while AnxA1 displays selectivity for binding to ALX, the shorter and more flexible peptide Ac2-26, binds to both FPR and ALX with approximately equal affinity [16].
Positive_regulation (transfected) of Gene_expression (transfected) of ALX
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.29 Pain Relevance 0.10

General Comments

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