INT332528

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.53
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (JAM3) extracellular region (JAM3) cell adhesion (JAM3)
plasma membrane (JAM3)
Anatomy Link Frequency
leukocyte 2
JAM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 9 97.64 Very High Very High Very High
Inflammation 84 88.80 High High
Osteoarthritis 3 84.48 Quite High
agonist 6 75.00 Quite High
Arthritis 3 72.64 Quite High
aspirin 3 71.36 Quite High
cINOD 15 20.60 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 6 97.92 Very High Very High Very High
Rheumatoid Arthritis 9 97.64 Very High Very High Very High
Disease 6 97.52 Very High Very High Very High
Adhesions 6 91.04 High High
INFLAMMATION 96 88.80 High High
Osteoarthritis 3 84.48 Quite High
Cancer 9 76.92 Quite High
Apoptosis 15 41.16 Quite Low
Brain Injury 3 24.96 Low Low
Colitis 3 23.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The down-regulation of JAM3 is also interesting as it is involved in leukocyte migration [23], a process in which AnxA1 have already been implicated.
Regulation (regulation) of JAM3 in leukocyte
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.23 Pain Relevance 0.12
Up-regulation of this gene, as well as JAG1 (and down-regulation of JAM3), was confirmed using real time PCR both with transfected HEK293 cells and human peripheral blood leukocytes.
Regulation (regulation) of JAM3 in leukocytes
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2941452 Disease Relevance 0.28 Pain Relevance 0.22
Moreover, targeting JAM3 significantly reduced the severity of experimental arthritic disease [24], [25].
Regulation (targeting) of JAM3 associated with disease and arthritis
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 1.02 Pain Relevance 0.32

General Comments

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