INT332536

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (9030425E11Rik) molecular_function (9030425E11Rik) biological_process (9030425E11Rik)
Anatomy Link Frequency
neuronal 1
dopaminergic neurons 1
9030425E11Rik (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 6 97.52 Very High Very High Very High
Substantia nigra 36 93.96 High High
Dopamine 36 89.24 High High
imagery 6 69.24 Quite High
Central nervous system 18 28.00 Quite Low
addiction 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 46 99.68 Very High Very High Very High
Infection 8 89.00 High High
Parkinson's Disease 30 36.56 Quite Low
Cancer 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 6 5.00 Very Low Very Low Very Low
Hypokinesia 2 5.00 Very Low Very Low Very Low
Rabies Virus Infection 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Tremor 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We studied the cellular localization of the hCAR protein in the transgenic animals in more detail using dual-label immunohistochemistry. hCAR was not seen to localize with the astrocyte marker ALDHL1 in the SN (Figure S1 A, B), nor with the neuronal marker MAP2 in the cortex, SN or STR (Figure S1 C–H).
Localization (localization) of hCAR protein in neuronal associated with targeted disruption and substantia nigra
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.27 Pain Relevance 0.19
Interestingly, hCAR protein localizes with markers of post-synaptic structures, suggesting synapses are the point of entry into dopaminergic neurons in transgenic animals.


Localization (localizes) of hCAR protein in dopaminergic neurons associated with targeted disruption
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2941453 Disease Relevance 0.60 Pain Relevance 0.32

General Comments

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