INT332592

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 9.21
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MND1) DNA binding (MND1)
Anatomy Link Frequency
plasma cell 1
MND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
peripheral neuropathy 10 91.12 High High
Inflammation 5 84.16 Quite High
Spinal cord 10 80.80 Quite High
Pain 10 38.64 Quite Low
Action potential 10 5.00 Very Low Very Low Very Low
cva 10 5.00 Very Low Very Low Very Low
Neuritis 5 5.00 Very Low Very Low Very Low
peptic ulcer disease 5 5.00 Very Low Very Low Very Low
nud 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 440 100.00 Very High Very High Very High
Lymphoproliferative Disease 40 99.80 Very High Very High Very High
Benign Monoclonal Gammopathies 5 99.80 Very High Very High Very High
Hypercalcemia 190 99.64 Very High Very High Very High
Neurological Disease 10 98.80 Very High Very High Very High
Paraproteinemias 40 98.60 Very High Very High Very High
Macroglobulinemia 10 97.12 Very High Very High Very High
Malignant Neoplastic Disease 60 96.84 Very High Very High Very High
Spinal Muscular Atrophy 15 95.52 Very High Very High Very High
Megaloblastic Anemia 5 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Various reports have also shown associations between MND and other paraproteins, including IgG, IgA, M proteins, Bence-Jones proteins, and polyclonal gammopathies.
MND Binding (associations) of associated with motor neuron diseases
1) Confidence 0.08 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 1.91 Pain Relevance 0.04
Other reports highlight the association of MND and the presence of a lymphoplasmocytoid infiltration of Waldenstrom's macroglobulinemia in particular, and the disappointing lack of neuromuscular improvement following treatment of the underlying hemopathy with plasmapheresis and immunosuppressive therapy [5].
MND Binding (association) of associated with macroglobulinemia and motor neuron diseases
2) Confidence 0.08 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 1.81 Pain Relevance 0
Although there are interesting correlations between PHP and SHP, MND/ALS with aberrant calcium, vitamin D, and PTH metabolism, most of the literature does not indicate a conclusive relationship between ALS and PHP/SHP and treatment of PHP/SHP does not lead to improvement of MND.


MND Binding (improvement) of associated with hypercalcemia and motor neuron diseases
3) Confidence 0.06 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 2.37 Pain Relevance 0.09
The association between MND and LPD could be coincidental, but LPD seems to be disproportionately frequent in patients with MND compared to the population in general [5].
MND Binding (association) of associated with lymphoproliferative disease and motor neuron diseases
4) Confidence 0.06 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 1.62 Pain Relevance 0.04
These results corroborate the concept of a probable association between MND and benign monoclonal gammopathy (plasma cell dyscrasias).
MND Binding (association) of in plasma cell associated with paraproteinemias, benign monoclonal gammopathies and motor neuron diseases
5) Confidence 0.06 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 1.50 Pain Relevance 0

General Comments

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